UniProt:O60725 ICMT

chain
  • chain:1-284
checksum C86741B13ACA611C
comment
  • FUNCTION Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.CATALYTIC ACTIVITY [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteineACTIVITY REGULATION Competitively inhibited by N-acetyl-S-trans,trans-farnesyl-l-cysteine (AFC).INTERACTION Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.SIMILARITY Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
crossReference
databaseName UniProt
dbId 57042
description
  • recommendedName: Protein-S-isoprenylcysteine O-methyltransferase ecNumber evidence="6"2.1.1.100 alternativeName: Isoprenylcysteine carboxylmethyltransferase alternativeName: Prenylated protein carboxyl methyltransferase shortName: PPMT alternativeName: Prenylcysteine carboxyl methyltransferase shortName: pcCMT
displayName UniProt:O60725 ICMT
geneName
  • ICMT
  • PCCMT
identifier O60725
isSequenceChanged false
keyword
  • Endoplasmic reticulum
  • Membrane
  • Methyltransferase
  • Proteomics identification
  • Reference proteome
  • S-adenosyl-L-methionine
  • Transferase
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ICMT
otherIdentifier
  • 11716323_at
  • 11716324_a_at
  • 16681082
  • 201609_PM_x_at
  • 201609_x_at
  • 201610_3p_at
  • 201610_PM_at
  • 201610_at
  • 201611_PM_s_at
  • 201611_s_at
  • 23463
  • 2394587
  • 2394589
  • 2394590
  • 2394591
  • 2394592
  • 2394593
  • 2394594
  • 2394595
  • 2394596
  • 2394597
  • 2394598
  • 2394599
  • 2394600
  • 2394601
  • 2394602
  • 2394603
  • 41775_at
  • 7911993
  • A_23_P104065
  • A_24_P128524
  • A_33_P3381022
  • GE61187
  • GO:0003824
  • GO:0003880
  • GO:0004671
  • GO:0005515
  • GO:0005783
  • GO:0005789
  • GO:0006481
  • GO:0006520
  • GO:0006575
  • GO:0006612
  • GO:0006790
  • GO:0006998
  • GO:0008168
  • GO:0016020
  • GO:0016740
  • GO:0032259
  • GO:0036211
  • GO:0046498
  • GO:0046499
  • GO:0051604
  • GO:0055086
  • GO:0061024
  • GO:0140096
  • GO:1901135
  • HMNXSV003028030
  • HMNXSV003045600
  • Hs.183212.0.S1_3p_a_at
  • Hs.183212.0.S3_3p_x_at
  • ILMN_1723021
  • ILMN_1744500
  • PH_hs_0010812
  • TC01002147.hg
  • g6912429_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ICMT_HUMAN
  • Q6FHT0
sequenceLength 284
species [Species:48887] Homo sapiens
stId uniprot:O60725
url http://purl.uniprot.org/uniprot/O60725
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