UniProt:O60684 KPNA6

chain
  • chain:1-536
checksum 9D0E27482B9BDED3
comment
  • FUNCTION Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.SUBUNIT Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1.SUBUNIT (Microbial infection) Interacts with ebolavirus protein VP24.SUBUNIT (Microbial infection) Interacts with human parainfluenza virus type 2 proteins P and V.INTERACTION Widely expressed.SIMILARITY Belongs to the importin alpha family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 148817
description
  • recommendedName: Importin subunit alpha-7 alternativeName: Karyopherin subunit alpha-6
displayName UniProt:O60684 KPNA6
geneName
  • KPNA6
  • IPOA7
identifier O60684
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Host-virus interaction
  • Phosphoprotein
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • KPNA6
otherIdentifier
  • 11723267_a_at
  • 11723268_at
  • 11723269_at
  • 11723270_x_at
  • 11723271_x_at
  • 16661956
  • 212101_PM_at
  • 212101_at
  • 212102_PM_s_at
  • 212102_s_at
  • 212103_3p_at
  • 212103_PM_at
  • 212103_at
  • 226976_PM_at
  • 226976_at
  • 2328675
  • 2328683
  • 2328685
  • 2328686
  • 2328687
  • 2328688
  • 2328689
  • 2328690
  • 2328692
  • 2328693
  • 2328694
  • 2328696
  • 2328697
  • 2328698
  • 2328699
  • 2328700
  • 2328701
  • 2328702
  • 2328703
  • 2328704
  • 2328705
  • 2328706
  • 2328707
  • 2328714
  • 2328715
  • 2328716
  • 2328717
  • 2328718
  • 2328719
  • 2328720
  • 23633
  • 35443_at
  • 40275_at
  • 43029_at
  • 44151_at
  • 7899688
  • A_24_P128563
  • A_33_P3214874
  • GE62857
  • GE81786
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0006351
  • GO:0006355
  • GO:0006366
  • GO:0006606
  • GO:0006607
  • GO:0006886
  • GO:0006913
  • GO:0008139
  • GO:0015031
  • GO:0016020
  • GO:0019079
  • GO:0022414
  • GO:0042564
  • GO:0043657
  • GO:0045944
  • GO:0060135
  • GO:0061608
  • GO:0075506
  • GO:0140104
  • GO:1900017
  • GO:1903902
  • HMNXSV003032512
  • HMNXSV003050048
  • Hs.301553.0.S1_3p_at
  • Hs.301553.1.S2_3p_a_at
  • Hs.301553.1.S3_3p_at
  • ILMN_1696021
  • PH_hs_0024219
  • TC01000419.hg
  • TC01004298.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IMA7_HUMAN
  • B2RDC7
  • D3DPP5
  • Q5VVU3
sequenceLength 536
species [Species:48887] Homo sapiens
stId uniprot:O60684
url http://purl.uniprot.org/uniprot/O60684

Referrals

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