UniProt:O60306 AQR

chain
  • chain:1-1485
checksum D0ADDA621A9418FD
comment
  • FUNCTION Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28076346, PubMed:28502770). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Identified in the spliceosome C complex (PubMed:11991638, PubMed:16949364, PubMed:25599396, PubMed:28076346, PubMed:28502770). Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE (PubMed:17981804). Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex (PubMed:25599396). The IB complex does not contain PRPF19 (PubMed:25599396). Within the spliceosome, interacts with SNRPA1, SF3B1, SF3B3, SF3A1 and SF3A2 (PubMed:25599396).INTERACTION Localizes to speckle-like regions of the nucleoplasm.DOMAIN Contains an N-terminal domain with structural similarity to ARM repeat regions; this domain functions as a scaffold for protein-protein interactions, but is not required for RNA binding or for ATP-dependent RNA helicase activity.SIMILARITY Belongs to the CWF11 family.SEQUENCE CAUTION Extended N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 218947
description
  • recommendedName: fullName evidence="9"RNA helicase aquarius ecNumber evidence="5"3.6.4.13 alternativeName: fullName evidence="8"Intron-binding protein of 160 kDa shortName evidence="8"IBP160
displayName UniProt:O60306 AQR
geneName
  • AQR
  • KIAA0560
identifier O60306
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • ATP-binding
  • Helicase
  • Hydrolase
  • mRNA processing
  • mRNA splicing
  • Nucleotide-binding
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • RNA-binding
  • Spliceosome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • AQR
otherIdentifier
  • 11742845_at
  • 11759408_at
  • 16807027
  • 212583_PM_at
  • 212583_at
  • 212584_PM_at
  • 212584_at
  • 228694_PM_at
  • 228694_at
  • 239895_at
  • 3348862
  • 3453746
  • 3617752
  • 3617754
  • 3617756
  • 3617758
  • 3617759
  • 3617760
  • 3617762
  • 3617764
  • 3617765
  • 3617766
  • 3617769
  • 3617770
  • 3617772
  • 3617775
  • 3617776
  • 3617777
  • 3617778
  • 3617779
  • 3617780
  • 3617781
  • 3617784
  • 3617785
  • 3617786
  • 3617787
  • 3617788
  • 3617789
  • 3617790
  • 3617791
  • 3617792
  • 3617793
  • 3617794
  • 3617795
  • 3617796
  • 3617797
  • 3617799
  • 3617800
  • 3617801
  • 3617804
  • 3617806
  • 3617807
  • 3617808
  • 3617809
  • 3617810
  • 3617811
  • 3617812
  • 3617813
  • 3617814
  • 3617816
  • 3617817
  • 3617819
  • 3617820
  • 3617821
  • 4015760
  • 41712_at
  • 58366_at
  • 7987325
  • 9716
  • A_24_P280378
  • A_24_P316305
  • A_24_P749042
  • GE624529
  • GE894794
  • GO:0000166
  • GO:0000398
  • GO:0003723
  • GO:0003724
  • GO:0003727
  • GO:0003729
  • GO:0003824
  • GO:0004386
  • GO:0005515
  • GO:0005524
  • GO:0005634
  • GO:0005654
  • GO:0005681
  • GO:0006397
  • GO:0008380
  • GO:0016020
  • GO:0016071
  • GO:0016787
  • GO:0016887
  • GO:0034458
  • GO:0071007
  • GO:0071013
  • GO:0140098
  • GO:0140657
  • HMNXSV003034877
  • HMNXSV003052375
  • Hs.129952.0.S1_3p_at
  • Hs.129952.0.S2_3p_at
  • Hs.16886.0.A1_3p_at
  • Hs.253582.0.A1_3p_at
  • ILMN_1717154
  • ILMN_2177460
  • PH_hs_0016401
  • PH_hs_0040773
  • TC15001202.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AQR_HUMAN
  • A0JP17
  • A5YKK3
  • Q2YDX9
  • Q6IRU8
  • Q6PIC8
sequenceLength 1485
species [Species:48887] Homo sapiens
stId uniprot:O60306
url http://purl.uniprot.org/uniprot/O60306
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