Reactome | UniProt:O60271 SPAG9

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UniProt:O60271 SPAG9 Show undefined attributes

chain	chain:1-1321
checksum	5CAE349FBDF91B40
comment	FUNCTION The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity).ACTIVITY REGULATION May play a role in spermatozoa-egg-interaction.SUBUNIT Homodimer (PubMed:19644450). The homodimer interacts with ARF6, forming a heterotetramer (PubMed:19644450). Homooligomer (PubMed:19644450). Interacts with MAX, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4 (By similarity). Interaction with KNS2 is important in the formation of ternary complex with MAPK8 (By similarity). Interacts with NFKB1 (PubMed:14743216). Interacts with PIP4P1 (PubMed:29146937). Interacts with PIKFYVE (By similarity).SUBUNIT Interacts with MAPK8, MAPK9, MAPK10.INTERACTION Perinuclear distribution in response to stress signals such as UV radiation.SUBCELLULAR LOCATION Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.ALTERNATIVE PRODUCTS Expressed only in testis on the round spermatids of stage I, II and II. Absent in spermatogonia and spermatocyte.TISSUE SPECIFICITY Expressed in testis and in acute myeloid leukemia (AML) patients.TISSUE SPECIFICITY Expressed in testis.INDUCTION Increased in systemic sclerosis fibroblasts.PTM Phosphorylated by MAPK8 and MAPK14.MISCELLANEOUS Due to intron retention.SIMILARITY Belongs to the JIP scaffold family.SEQUENCE CAUTION Probable cloning artifact.SEQUENCE CAUTION Probable cloning artifact.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the C-terminal part.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Unlikely isoform. Aberrant splicing.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11481490] ENSEMBL:ENSG00000008294 [DatabaseIdentifier:11582648] ENSEMBL:ENSP00000426900 [DatabaseIdentifier:11582650] ENSEMBL:ENSP00000262013 [DatabaseIdentifier:11582651] ENSEMBL:ENSP00000423165 [DatabaseIdentifier:11582649] ENSEMBL:ENSP00000349636 [DatabaseIdentifier:11705348] ENSEMBL:ENST00000357122 [DatabaseIdentifier:11705350] ENSEMBL:ENST00000510283 [DatabaseIdentifier:11705347] ENSEMBL:ENST00000262013 [DatabaseIdentifier:11705349] ENSEMBL:ENST00000505279 [DatabaseIdentifier:11794024] GeneCards:SPAG9 [DatabaseIdentifier:11809970] GlyGen:O60271 [DatabaseIdentifier:11847010] HPA:ENSG00000008294-SPAG9 [DatabaseIdentifier:12131675] OpenTargets:ENSG00000008294 [DatabaseIdentifier:12174539] PDB:2W83 [DatabaseIdentifier:12274666] PRO:O60271 [DatabaseIdentifier:12291862] Pharos - Targets:O60271 [DatabaseIdentifier:12387926] RefSeq:NP_001123999.1 [DatabaseIdentifier:12387927] RefSeq:NP_001238900.1 [DatabaseIdentifier:12387928] RefSeq:NP_003962.3 [DatabaseIdentifier:12387929] RefSeq:NP_001124000.1
databaseName	UniProt
dbId	233262
description	recommendedName: C-Jun-amino-terminal kinase-interacting protein 4 shortName: JIP-4 shortName: JNK-interacting protein 4 alternativeName: Cancer/testis antigen 89 shortName: CT89 alternativeName: Human lung cancer oncogene 6 protein shortName: HLC-6 alternativeName: JNK-associated leucine-zipper protein shortName: JLP alternativeName: Mitogen-activated protein kinase 8-interacting protein 4 alternativeName: Proliferation-inducing protein 6 alternativeName: Protein highly expressed in testis shortName: PHET alternativeName: Sperm surface protein alternativeName: Sperm-associated antigen 9 alternativeName: Sperm-specific protein alternativeName: Sunday driver 1
displayName	UniProt:O60271 SPAG9
geneName	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6
identifier	O60271
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Coiled coil Cytoplasm Cytoplasmic vesicle Lysosome Membrane Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SPAG9
otherIdentifier	11718896_x_at 11718897_at 11718898_s_at 11744885_a_at 11744886_a_at 11752767_a_at 11755000_a_at 11759839_a_at 11760212_at 1554543_3p_at 1554543_PM_at 1554543_at 16846745 206748_PM_s_at 206748_s_at 212468_PM_at 212468_at 212470_PM_at 212470_at 225339_PM_at 225339_at 3762520 3762521 3762522 3762523 3762525 3762526 3762527 3762528 3762529 3762530 3762532 3762533 3762534 3762535 3762536 3762537 3762538 3762539 3762540 3762541 3762542 3762543 3762544 3762545 3762546 3762547 3762548 3762549 3762550 3762551 3762552 3762553 3762554 3762555 3762556 3762557 3762559 3762560 3762561 3762562 3762564 3762565 3762566 3762567 3762568 3762569 3762570 3762571 3762572 3762573 3762574 3762575 3762576 3762582 3762583 3762584 3762585 3762586 3762588 3762589 3762591 3762592 3762593 3762594 3762598 3762599 3762608 3762609 39419_at 58452_at 73574_at 78444_at 78446_g_at 8016745 84489_at 88206_r_at 9043 A_23_P207476 A_23_P356041 A_24_P365025 A_24_P8454 A_24_P942469 GE81338 GE86976 GO:0000165 GO:0001669 GO:0005078 GO:0005515 GO:0005737 GO:0005764 GO:0005765 GO:0005829 GO:0008092 GO:0008432 GO:0016020 GO:0016192 GO:0019894 GO:0030154 GO:0030159 GO:0030335 GO:0031410 GO:0032418 GO:0034451 GO:0042147 GO:0042802 GO:0043410 GO:0045665 GO:0045666 GO:0048471 GO:0051146 GO:0060090 GO:0070062 GO:1903860 HMNXSV003004074 HMNXSV003014574 Hs.129872.1.S1_3p_at Hs.129872.1.S2_3p_at Hs.129872.2.S1_3p_at Hs2.129872.3.S1_3p_x_at ILMN_1728256 ILMN_1768798 ILMN_1799104 ILMN_2263718 PH_hs_0026535 TC17001700.hg TC17001701.hg g4504524_3p_a_at g4504524_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-375975] SPAG9 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000008294] ENSEMBL:ENSG00000008294 SPAG9 [ReferenceDNASequence:12743046] UCSC:O60271 SPAG9 [ReferenceDNASequence:11346910] BioGPS Gene:9043 SPAG9 [ReferenceDNASequence:11400188] COSMIC - genes:SPAG9 SPAG9 [ReferenceDNASequence:11422671] CTD Gene:9043 SPAG9 [ReferenceDNASequence:11437300] dbSNP Gene:9043 SPAG9 [ReferenceDNASequence:11825719] HGNC:14524 SPAG9 [ReferenceDNASequence:11886995] KEGG:hsa:9043 SPAG9 [ReferenceDNASequence:11976699] Monarch:9043 SPAG9 [ReferenceDNASequence:12060792] NCBI Gene:9043 SPAG9 [ReferenceDNASequence:12116115] OMIM:605430 SPAG9
referenceTranscript	[ReferenceRNASequence:12569720] RefSeq:NM_001130527.3 SPAG9 [ReferenceRNASequence:12569717] RefSeq:NM_001251971.2 SPAG9 [ReferenceRNASequence:12569719] RefSeq:NM_001130528.3 SPAG9 [ReferenceRNASequence:12569718] RefSeq:NM_003971.5 SPAG9
schemaClass	ReferenceGeneProduct
secondaryIdentifier	JIP4_HUMAN A6H8U5 A8MSX0 B4DHH2 O60905 Q3KQU8 Q3MKM7 Q86WC7 Q86WC8 Q8IZX7 Q96II0 Q9H811
sequenceLength	1321
species	[Species:48887] Homo sapiens
stId	uniprot:O60271
url	http://purl.uniprot.org/uniprot/O60271

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[EntityWithAccessionedSequence:R-HSA-375975] SPAG9 [cytosol]

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