Reactome | UniProt:O60244 MED14

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UniProt:O60244 MED14 Show undefined attributes

chain	chain:1-1454
checksum	144308E3F08D3D9B
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Interacts with GATA1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2.INTERACTION Ubiquitous.SIMILARITY Belongs to the Mediator complex subunit 14 family.
created	[InstanceEdit:212200] Caudy, M, 2008-02-08 20:35:02
crossReference	[DatabaseIdentifier:11481502] ENSEMBL:ENSG00000180182 [DatabaseIdentifier:12387954] RefSeq:NP_004220.2 [DatabaseIdentifier:12291879] Pharos - Targets:O60244 [DatabaseIdentifier:12274689] PRO:O60244 [DatabaseIdentifier:12139977] PDB:8GXQ [DatabaseIdentifier:12139983] PDB:7EMF [DatabaseIdentifier:12139975] PDB:7ENJ [DatabaseIdentifier:12139980] PDB:7ENC [DatabaseIdentifier:12139982] PDB:7ENA [DatabaseIdentifier:12139978] PDB:8TQW [DatabaseIdentifier:12139976] PDB:8GXS [DatabaseIdentifier:12139981] PDB:7NVR [DatabaseIdentifier:12139979] PDB:8TRH [DatabaseIdentifier:12139984] PDB:8T9D [DatabaseIdentifier:12138290] PDB:7LBM [DatabaseIdentifier:12131693] OpenTargets:ENSG00000180182 [DatabaseIdentifier:11582667] ENSEMBL:ENSP00000323720 [DatabaseIdentifier:11705366] ENSEMBL:ENST00000324817 [DatabaseIdentifier:11794042] GeneCards:MED14 [DatabaseIdentifier:11809984] GlyGen:O60244 [DatabaseIdentifier:11847027] HPA:ENSG00000180182-MED14
databaseName	UniProt
dbId	212195
description	recommendedName: Mediator of RNA polymerase II transcription subunit 14 alternativeName: Activator-recruited cofactor 150 kDa component shortName: ARC150 alternativeName: Cofactor required for Sp1 transcriptional activation subunit 2 shortName: CRSP complex subunit 2 alternativeName: Mediator complex subunit 14 alternativeName: RGR1 homolog shortName: hRGR1 alternativeName: Thyroid hormone receptor-associated protein complex 170 kDa component shortName: Trap170 alternativeName: Transcriptional coactivator CRSP150 alternativeName: Vitamin D3 receptor-interacting protein complex 150 kDa component shortName: DRIP150
displayName	UniProt:O60244 MED14
geneName	MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170
identifier	O60244
isSequenceChanged	false
keyword	3D-structure Activator Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	MED14
otherIdentifier	11728675_a_at 11728676_at 11759000_at 17110193 202610_PM_s_at 202610_s_at 202611_PM_s_at 202611_s_at 202612_PM_s_at 202612_s_at 215167_PM_at 215167_at 33344_at 4005640 4005641 4005642 4005643 4005645 4005646 4005647 4005648 4005649 4005650 4005655 4005656 4005657 4005659 4005660 4005661 4005663 4005664 4005665 4005666 4005667 4005668 4005670 4005671 4005672 4005674 4005675 4005676 4005677 4005678 4005679 4005680 4005682 4005684 4005685 4005687 4005688 4005692 4005693 4005696 4005698 4005699 4005700 4005702 4005703 4005704 4005705 4005706 4005708 4005709 4005710 8172119 9282 A_23_P21120 A_23_P72187 A_33_P3223749 GE53137 GO:0003712 GO:0003713 GO:0005515 GO:0005634 GO:0005654 GO:0006355 GO:0006357 GO:0016020 GO:0016592 GO:0032968 GO:0035019 GO:0042809 GO:0045893 GO:0045944 GO:0051123 GO:0060261 GO:0065003 GO:0070847 HMNXSV003005781 HMNXSV003023080 Hs.21586.0.A2_3p_a_at Hs.21586.2.S1_3p_at ILMN_1686151 ILMN_1739956 ILMN_1770088 ILMN_1813909 PH_hs_0019423 TC0X000966.hg g4580325_3p_a_at g4758101_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-212441] MED14 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11976721] Monarch:9282 MED14 [ReferenceDNASequence:12743065] UCSC:O60244 MED14 [ReferenceDNASequence:12116130] OMIM:300182 MED14 [ReferenceDNASequence:12060814] NCBI Gene:9282 MED14 [ReferenceDNASequence:ensembl:ENSG00000180182] ENSEMBL:ENSG00000180182 MED14 [ReferenceDNASequence:11346932] BioGPS Gene:9282 MED14 [ReferenceDNASequence:11400193] COSMIC - genes:MED14 MED14 [ReferenceDNASequence:11422699] CTD Gene:9282 MED14 [ReferenceDNASequence:11437305] dbSNP Gene:9282 MED14 [ReferenceDNASequence:11825737] HGNC:2370 MED14 [ReferenceDNASequence:11887016] KEGG:hsa:9282 MED14
referenceTranscript	[ReferenceRNASequence:12569743] RefSeq:NM_004229.3 MED14
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MED14_HUMAN Q4KMR7 Q9UNB3
sequenceLength	1454
species	[Species:48887] Homo sapiens
stId	uniprot:O60244
url	http://purl.uniprot.org/uniprot/O60244

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[EntityWithAccessionedSequence:R-HSA-212441] MED14 [nucleoplasm]

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