Reactome | UniProt:O60229 KALRN

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UniProt:O60229 KALRN Show undefined attributes

chain	chain:1-2986
checksum	EA7B559A9E4AFFA0
comment	FUNCTION Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.INTERACTION Associated with the cytoskeleton.ALTERNATIVE PRODUCTS Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.DOMAIN The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).PTM Autophosphorylated.MISCELLANEOUS Called DUO because the encoded protein is closely related to but shorter than TRIO.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Probable cloning artifact.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:12388041] RefSeq:NP_001309925.1 [DatabaseIdentifier:12388053] RefSeq:NP_001309926.1 [DatabaseIdentifier:12388048] RefSeq:NP_001309918.1 [DatabaseIdentifier:12388049] RefSeq:NP_001309929.1 [DatabaseIdentifier:12388044] RefSeq:NP_001309923.1 [DatabaseIdentifier:12388054] RefSeq:NP_001019831.2 [DatabaseIdentifier:12388052] RefSeq:NP_001309927.1 [DatabaseIdentifier:12388042] RefSeq:NP_001309924.1 [DatabaseIdentifier:12388043] RefSeq:NP_001375348.1 [DatabaseIdentifier:12388045] RefSeq:NP_003938.1 [DatabaseIdentifier:12388051] RefSeq:NP_001309928.1 [DatabaseIdentifier:12388050] RefSeq:NP_001309917.1 [DatabaseIdentifier:12388047] RefSeq:NP_008995.2 [DatabaseIdentifier:11481544] ENSEMBL:ENSG00000160145 [DatabaseIdentifier:11582730] ENSEMBL:ENSP00000353109 [DatabaseIdentifier:11582729] ENSEMBL:ENSP00000240874 [DatabaseIdentifier:11582728] ENSEMBL:ENSP00000291478 [DatabaseIdentifier:11705428] ENSEMBL:ENST00000291478 [DatabaseIdentifier:11705427] ENSEMBL:ENST00000360013 [DatabaseIdentifier:11705429] ENSEMBL:ENST00000240874 [DatabaseIdentifier:11780509] Guide to Pharmacology - Targets:2050 [DatabaseIdentifier:11794088] GeneCards:KALRN [DatabaseIdentifier:11810030] GlyGen:O60229 [DatabaseIdentifier:11830975] HMDB Protein:HMDBP08472 [DatabaseIdentifier:11847072] HPA:ENSG00000160145-KALRN [DatabaseIdentifier:12131739] OpenTargets:ENSG00000160145 [DatabaseIdentifier:12165525] PDB:5QQH [DatabaseIdentifier:12165531] PDB:5QQK [DatabaseIdentifier:12165522] PDB:5QQF [DatabaseIdentifier:12165517] PDB:5QQN [DatabaseIdentifier:12165518] PDB:5QQM [DatabaseIdentifier:12165535] PDB:5QU9 [DatabaseIdentifier:12220528] PDB:8C7D [DatabaseIdentifier:12165530] PDB:5QQL [DatabaseIdentifier:12165529] PDB:5QQI [DatabaseIdentifier:12165527] PDB:5QQG [DatabaseIdentifier:12165528] PDB:5QQJ [DatabaseIdentifier:12165534] PDB:5QQD [DatabaseIdentifier:12165524] PDB:5QQE [DatabaseIdentifier:12274735] PRO:O60229 [DatabaseIdentifier:12291924] Pharos - Targets:O60229 [DatabaseIdentifier:12388046] RefSeq:NP_001309930.1
databaseName	UniProt
dbId	401664
description	recommendedName: fullName evidence="3"Kalirin ecNumber: 2.7.11.1 alternativeName: Huntingtin-associated protein-interacting protein alternativeName: Protein Duo alternativeName: Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
displayName	UniProt:O60229 KALRN
geneName	KALRN DUET DUO HAPIP TRAD
identifier	O60229
isSequenceChanged	false
keyword	3D-structure Alternative splicing ATP-binding Cytoplasm Cytoskeleton Disulfide bond Guanine-nucleotide releasing factor Immunoglobulin domain Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Repeat Serine/threonine-protein kinase SH3 domain Transferase
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	KALRN
otherIdentifier	11728160_at 11732547_a_at 11740771_a_at 11761443_a_at 16944798 16944912 205635_PM_at 205635_at 206078_PM_at 206078_at 227750_PM_at 227750_at 230596_PM_at 230596_at 236651_PM_at 236651_at 2639553 2639554 2639555 2639572 2639574 2639579 2639580 2639581 2639582 2639583 2639584 2639587 2639588 2639603 2639604 2639605 2639611 2639617 2639618 2639624 2639625 2639626 2639627 2639633 2639636 2639640 2639643 2639646 2639655 2639656 2639657 2639658 2639661 2639662 2639663 2639664 2639666 2639668 2639673 2639674 2639677 2639678 2639682 2639685 2639689 2639691 2639694 2639695 2639697 2639698 2639700 2639701 2639704 2639705 2639706 2639707 2639708 2639709 2639710 2639711 2639712 2639719 2639720 2639721 2639722 2639723 2639735 2639741 2639742 2639754 2639755 2639758 2639763 2639764 2639765 2639766 2639767 2639768 2639769 2639770 2639772 2639773 2639776 2639777 2639780 2639781 2639782 2639783 2639784 2639785 2639786 2639787 2639788 2639789 2639790 2639791 2639801 2639802 2639803 2639804 2639805 2639806 2639807 2639808 2639809 2639810 2639813 2639814 2639815 2639816 2639858 2639870 2639872 2639873 2639875 2639876 2639877 2639878 2639879 2639880 3378272 35406_at 40655_at 43143_at 55541_f_at 58195_at 60043_at 64267_f_at 75375_at 8082165 87055_at 8997 A_14_P101744 A_14_P108281 A_14_P115189 A_14_P133955 A_21_P0000554 A_23_P307563 A_24_P328524 A_24_P410797 A_32_P207481 A_33_P3219121 A_33_P3219138 GE59579 GE760573 GE80203 GE809710 GO:0000166 GO:0003824 GO:0004672 GO:0004674 GO:0005085 GO:0005515 GO:0005524 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0006468 GO:0007165 GO:0007399 GO:0007411 GO:0014069 GO:0015629 GO:0016192 GO:0016301 GO:0016740 GO:0019898 GO:0035556 GO:0043226 GO:0046872 GO:0048013 GO:0048856 GO:0051056 GO:0070062 GO:0106310 GO:0140096 HMNXSV003014426 HMNXSV003028059 HMNXSV003034596 HMNXSV003056803 HMNXSV003058048 HMNXSV003058231 Hs.13281.0.A1_3p_at Hs.143061.0.A1_3p_at Hs.162189.1.S1_3p_at ILMN_1804661 ILMN_1812233 ILMN_2241750 PH_hs_0000847 PH_hs_0001277 PH_hs_0008413 PH_hs_0009841 TC03000642.hg TC03002503.hg TC03002504.hg g4504334_3p_at g5902139_3p_at p11946 p34371
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3006505] KALRN [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5692652] p-KALRN [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000160145] ENSEMBL:ENSG00000160145 KALRN [ReferenceDNASequence:12743090] UCSC:O60229 KALRN [ReferenceDNASequence:11346978] BioGPS Gene:8997 KALRN [ReferenceDNASequence:11400197] COSMIC - genes:KALRN KALRN [ReferenceDNASequence:11422755] CTD Gene:8997 KALRN [ReferenceDNASequence:11437311] dbSNP Gene:8997 KALRN [ReferenceDNASequence:11825783] HGNC:4814 KALRN [ReferenceDNASequence:11887060] KEGG:hsa:8997 KALRN [ReferenceDNASequence:11976767] Monarch:8997 KALRN [ReferenceDNASequence:12060860] NCBI Gene:8997 KALRN [ReferenceDNASequence:12116173] OMIM:604605 KALRN
referenceTranscript	[ReferenceRNASequence:12569832] RefSeq:NM_001024660.5 KALRN [ReferenceRNASequence:12569837] RefSeq:NM_001322989.1 KALRN [ReferenceRNASequence:12569829] RefSeq:NM_003947.6 KALRN [ReferenceRNASequence:12569840] RefSeq:NM_001388419.1 KALRN [ReferenceRNASequence:12569838] RefSeq:NM_007064.5 KALRN [ReferenceRNASequence:12569836] RefSeq:NM_001322999.1 KALRN [ReferenceRNASequence:12569834] RefSeq:NM_001322998.1 KALRN [ReferenceRNASequence:12569830] RefSeq:NM_001323000.1 KALRN [ReferenceRNASequence:12569842] RefSeq:NM_001322996.1 KALRN [ReferenceRNASequence:12569841] RefSeq:NM_001322995.1 KALRN [ReferenceRNASequence:12569835] RefSeq:NM_001322988.1 KALRN [ReferenceRNASequence:12569831] RefSeq:NM_001323001.1 KALRN [ReferenceRNASequence:12569839] RefSeq:NM_001322994.1 KALRN [ReferenceRNASequence:12569833] RefSeq:NM_001322997.1 KALRN
schemaClass	ReferenceGeneProduct
secondaryIdentifier	KALRN_HUMAN A0A804HLI0 A8MSI4 C9JQ37 J3QSW6 Q6ZN45 Q8TBQ5 Q9NSZ4 Q9Y2A5
sequenceLength	2986
species	[Species:48887] Homo sapiens
stId	uniprot:O60229
url	http://purl.uniprot.org/uniprot/O60229

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3006505] KALRN [cytosol] [EntityWithAccessionedSequence:R-HSA-5692652] p-KALRN [cytosol]
(referenceSequence)	[ModifiedResidue:5692653] phosphorylated residue at unknown position
(interactor)	[UndirectedInteraction:11232415] UniProt:O60229 <-> UniProt:P0DTD1-PRO_0000449633 (IntAct) [UndirectedInteraction:11232417] UniProt:O60229 <-> UniProt:P0DTD1-PRO_0000449631 (IntAct) [UndirectedInteraction:11232419] UniProt:O60229 <-> UniProt:Q9GZM8 (IntAct) [UndirectedInteraction:11232421] UniProt:O60229 <-> UniProt:Q9NRI5 (IntAct)