FUNCTION Required to maintain microtubule bundles in inner ear supporting cells, affording them with mechanical stiffness to transmit sound energy through the cochlea.INTERACTION Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). Colocalizes with detyrosinated alpha-tubulin along the length of microtubule bundles in inner and outer pillar cells (By similarity).ALTERNATIVE PRODUCTS Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.DEVELOPMENTAL STAGE Specifically expressed at growth arrest.PTM Cleaved, during apoptosis, on a specific aspartic residue by caspases.PTM Phosphorylated on serine residues during the G0-G1 transition phase.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GAS2 family.
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