Reactome | UniProt:O43508 TNFSF12

Schema > ReferenceGeneProduct > Entries

UniProt:O43508 TNFSF12 Show undefined attributes

chain	chain:1-249 chain:94-249
checksum	E660843361C28EBA
comment	FUNCTION Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.SUBUNIT Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.INTERACTION Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.PTM The soluble form derives from the membrane form by proteolytic processing.MISCELLANEOUS Based on a readthrough transcript which may produce a TWE-PRIL (TNFSF12-TNFSF13) fusion protein. Expressed at protein level in primary T-lymphocytes and monocytic cell lines.SIMILARITY Belongs to the tumor necrosis factor family.
crossReference	[DatabaseIdentifier:12403538] RefSeq:NP_742086.1 [DatabaseIdentifier:12403539] RefSeq:NP_003800.1 [DatabaseIdentifier:12282519] Pharos - Targets:O43508 [DatabaseIdentifier:12240397] PRO:O43508 [DatabaseIdentifier:12159432] PDB:4HT1 [DatabaseIdentifier:12136865] Orphanet:TNFSF12 [DatabaseIdentifier:12122197] OpenTargets:ENSG00000239697 [DatabaseIdentifier:11837700] HPA:ENSG00000239697-TNFSF12 [DatabaseIdentifier:11784605] GeneCards:TNFSF12 [DatabaseIdentifier:11715577] ENSEMBL:ENST00000293825 [DatabaseIdentifier:11592878] ENSEMBL:ENSP00000293825 [DatabaseIdentifier:11487809] ENSEMBL:ENSG00000239697
databaseName	UniProt
dbId	66191
description	recommendedName: Tumor necrosis factor ligand superfamily member 12 alternativeName: APO3 ligand alternativeName: TNF-related weak inducer of apoptosis shortName: TWEAK component recommendedName: Tumor necrosis factor ligand superfamily member 12, membrane form /component component recommendedName: Tumor necrosis factor ligand superfamily member 12, secreted form /component
displayName	UniProt:O43508 TNFSF12
geneName	TNFSF12 APO3L DR3LG UNQ181/PRO207
identifier	O43508
isSequenceChanged	false
keyword	3D-structure Alternative splicing Angiogenesis Apoptosis Cell membrane Cleavage on pair of basic residues Cytokine Developmental protein Differentiation Disulfide bond Glycoprotein Membrane Proteomics identification Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	TNFSF12
otherIdentifier	11719911_at 16830520 205611_PM_at 205611_at 3708763 3708765 3708766 3708767 3708768 3708769 3708770 3708771 3708772 3708773 3708774 3708775 3708776 3708777 3708778 3708779 3708780 39588_at 8004464 8742 A_14_P133055 A_24_P245298 A_33_P3406623 GE54528 GO:0001525 GO:0001938 GO:0002376 GO:0005102 GO:0005125 GO:0005164 GO:0005515 GO:0005576 GO:0005615 GO:0005886 GO:0006915 GO:0006955 GO:0007165 GO:0016020 GO:0030154 GO:0043542 GO:0045732 GO:0045766 GO:0048018 GO:0048471 GO:0048870 GO:0097191 GO:0098772 GO:2001238 HMNXSV003058400 ILMN_1670188 ILMN_1680003 ILMN_1683700 TC17002035.hg TC17002864.hg g4507596_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5667154] TNFSF12 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5675974] sTNFSF12 [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12746695] UCSC:O43508 TNFSF12 [ReferenceDNASequence:12107842] OMIM:602695 TNFSF12 [ReferenceDNASequence:12066973] NCBI Gene:8742 TNFSF12 [ReferenceDNASequence:11982880] Monarch:8742 TNFSF12 [ReferenceDNASequence:11892754] KEGG:hsa:407977 TNFSF12 [ReferenceDNASequence:11892753] KEGG:hsa:8742 TNFSF12 [ReferenceDNASequence:11816230] HGNC:11927 TNFSF12 [ReferenceDNASequence:11438339] dbSNP Gene:8742 TNFSF12 [ReferenceDNASequence:11408636] CTD Gene:8742 TNFSF12 [ReferenceDNASequence:11401076] COSMIC - genes:TNFSF12 TNFSF12 [ReferenceDNASequence:11353091] BioGPS Gene:8742 TNFSF12 [ReferenceDNASequence:ensembl:ENSG00000239697] ENSEMBL:ENSG00000239697 TNFSF12
referenceTranscript	[ReferenceRNASequence:12585257] RefSeq:NM_003809.3 TNFSF12 [ReferenceRNASequence:12585258] RefSeq:NM_172089.3 TNFSF12
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TNF12_HUMAN Q8IZK7 Q8WUZ7
sequenceLength	249
species	[Species:48887] Homo sapiens
stId	uniprot:O43508
url	http://purl.uniprot.org/uniprot/O43508

Referrals

(interactor)	[UndirectedInteraction:11288841] UniProt:Q9UPY3 <-> UniProt:O43508 (IntAct) [UndirectedInteraction:11273639] UniProt:P05067 <-> UniProt:O43508 (IntAct) [UndirectedInteraction:11266241] UniProt:Q9NP84 <-> UniProt:O43508 (IntAct) [UndirectedInteraction:11250099] UniProt:P35638 <-> UniProt:O43508 (IntAct) [UndirectedInteraction:11193013] UniProt:P06493 <-> UniProt:O43508 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5667154] TNFSF12 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-5675974] sTNFSF12 [extracellular region]