Reactome | UniProt:O43493 TGOLN2

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UniProt:O43493 TGOLN2 Show undefined attributes

chain	signal peptide:1-21 chain:22-437
checksum	6F72467FED83A1A3
comment	FUNCTION May be involved in regulating membrane traffic to and from trans-Golgi network.INTERACTION Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.ALTERNATIVE PRODUCTS Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.
crossReference	[DatabaseIdentifier:11487574] ENSEMBL:ENSG00000292253 [DatabaseIdentifier:11487573] ENSEMBL:ENSG00000152291 [DatabaseIdentifier:11592444] ENSEMBL:ENSP00000518212 [DatabaseIdentifier:11592443] ENSEMBL:ENSP00000391190 [DatabaseIdentifier:11592442] ENSEMBL:ENSP00000387035 [DatabaseIdentifier:11592446] ENSEMBL:ENSP00000366603 [DatabaseIdentifier:11592445] ENSEMBL:ENSP00000381312 [DatabaseIdentifier:11715141] ENSEMBL:ENST00000398263 [DatabaseIdentifier:11715145] ENSEMBL:ENST00000444342 [DatabaseIdentifier:11715143] ENSEMBL:ENST00000409015 [DatabaseIdentifier:11715144] ENSEMBL:ENST00000710332 [DatabaseIdentifier:11715142] ENSEMBL:ENST00000377386 [DatabaseIdentifier:11784463] GeneCards:TGOLN2 [DatabaseIdentifier:11799945] GlyGen:O43493 [DatabaseIdentifier:11837560] HPA:ENSG00000152291-TGOLN2 [DatabaseIdentifier:12122055] OpenTargets:ENSG00000152291 [DatabaseIdentifier:12158109] PDB:6YAF [DatabaseIdentifier:12240160] PRO:O43493 [DatabaseIdentifier:12282379] Pharos - Targets:O43493 [DatabaseIdentifier:12402834] RefSeq:NP_001193773.1 [DatabaseIdentifier:12402835] RefSeq:NP_001193770.1 [DatabaseIdentifier:12402832] RefSeq:NP_001193769.1 [DatabaseIdentifier:12402833] RefSeq:NP_001355024.1 [DatabaseIdentifier:12402836] RefSeq:NP_006455.2
databaseName	UniProt
dbId	65967
description	recommendedName: fullName evidence="10"Trans-Golgi network integral membrane protein 2 alternativeName: fullName evidence="9"Trans-Golgi network glycoprotein 46 shortName evidence="11"TGN38 homolog shortName evidence="9"hTGN46 alternativeName: fullName evidence="9"Trans-Golgi network glycoprotein 48 shortName evidence="9"hTGN48 alternativeName: fullName evidence="9"Trans-Golgi network glycoprotein 51 shortName evidence="9"hTGN51 alternativeName: fullName evidence="12"Trans-Golgi network protein 2
displayName	UniProt:O43493 TGOLN2
geneName	TGOLN2 TGN46 TGN51
identifier	O43493
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Glycoprotein Golgi apparatus Membrane Phosphoprotein Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	TGOLN2
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8956702] TGOLN2 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956886] p-TGOLN2 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8864458] TGOLN2 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8869127] TGOLN2 [clathrin-coated endocytic vesicle membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6811011] TGOLN2 [transport vesicle] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6811008] TGOLN2 [trans-Golgi network membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-429818] TGOLN2 [cytoplasmic vesicle membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-434342] TGOLN2 [Golgi membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000152291] ENSEMBL:ENSG00000152291 TGOLN2 [ReferenceDNASequence:12746443] UCSC:O43493 O434935 [ReferenceDNASequence:11352831] BioGPS Gene:10618 O434935 [ReferenceDNASequence:11401012] COSMIC - genes:TGOLN2 TGOLN2 [ReferenceDNASequence:11408422] CTD Gene:10618 O434935 [ReferenceDNASequence:11438273] dbSNP Gene:10618 TGOLN2 [ReferenceDNASequence:11816088] HGNC:15450 O434935 [ReferenceDNASequence:11892508] KEGG:hsa:10618 O434935 [ReferenceDNASequence:11982620] Monarch:10618 O434935 [ReferenceDNASequence:12066713] NCBI Gene:10618 O434935 [ReferenceDNASequence:12107707] OMIM:603062 O434935
referenceTranscript	[ReferenceRNASequence:12584568] RefSeq:NM_006464.3 O434935 [ReferenceRNASequence:12584564] RefSeq:NM_001206841.1 O434935 [ReferenceRNASequence:12584565] RefSeq:NM_001206840.1 O434935 [ReferenceRNASequence:12584566] RefSeq:NM_001206844.2 O434935 [ReferenceRNASequence:12584567] RefSeq:NM_001368095.1 O434935
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TGON2_HUMAN B2R686 B8ZZ88 D6W5K3 F8W8W7 F8WBK2 J3KQ45 O15282 O43492 O43499 O43500 O43501 Q53G68 Q53GV2 Q6MZV1 Q6ZTM7 Q8N6T8 Q92760 Q96QL2
sequenceLength	437
species	[Species:48887] Homo sapiens
stId	uniprot:O43493
url	http://purl.uniprot.org/uniprot/O43493

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8956702] TGOLN2 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8956886] p-TGOLN2 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8864458] TGOLN2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8869127] TGOLN2 [clathrin-coated endocytic vesicle membrane] [EntityWithAccessionedSequence:R-HSA-6811011] TGOLN2 [transport vesicle] [EntityWithAccessionedSequence:R-HSA-6811008] TGOLN2 [trans-Golgi network membrane] [EntityWithAccessionedSequence:R-HSA-429818] TGOLN2 [cytoplasmic vesicle membrane] [EntityWithAccessionedSequence:R-HSA-434342] TGOLN2 [Golgi membrane]
(referenceSequence)	[ModifiedResidue:8956950] phosphorylated residue at unknown position
(interactor)	[UndirectedInteraction:11182415] UniProt:P27986 <-> UniProt:O43493 (IntAct) [UndirectedInteraction:11206787] UniProt:Q9H3P7 <-> UniProt:O43493 (IntAct) [UndirectedInteraction:11279809] UniProt:O94822 <-> UniProt:O43493 (IntAct)

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