UniProt:O35678 Mgll

chain
  • chain:1-303
checksum CB753ECDE38EBEC1
comment
  • FUNCTION Converts monoacylglycerides to free fatty acids and glycerol (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity).CATALYTIC ACTIVITY Hydrolyzes glycerol monoesters of long-chain fatty acids.CATALYTIC ACTIVITY a 1-acylglycerol + H2O = glycerol + a fatty acid + H(+)CATALYTIC ACTIVITY a 2-acylglycerol + H2O = glycerol + a fatty acid + H(+)CATALYTIC ACTIVITY 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-octanoylglycerol + H2O = octanoate + glycerol + H(+)CATALYTIC ACTIVITY 1-decanoylglycerol + H2O = decanoate + glycerol + H(+)CATALYTIC ACTIVITY 1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)CATALYTIC ACTIVITY 1-tetradecanoylglycerol + H2O = tetradecanoate + glycerol + H(+)CATALYTIC ACTIVITY 2-hexadecanoylglycerol + H2O = glycerol + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)CATALYTIC ACTIVITY 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)CATALYTIC ACTIVITY 1-hexadecanoylglycerol + H2O = glycerol + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-octadecanoylglycerol + H2O = octadecanoate + glycerol + H(+)CATALYTIC ACTIVITY prostaglandin E2 1-glyceryl ester + H2O = prostaglandin E2 + glycerol + H(+)CATALYTIC ACTIVITY prostaglandin D2-1-glycerol ester + H2O = prostaglandin D2 + glycerol + H(+)CATALYTIC ACTIVITY 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)CATALYTIC ACTIVITY prostaglandin F2alpha 1-glyceryl ester + H2O = prostaglandin F2alpha + glycerol + H(+)PATHWAY Glycerolipid metabolism; triacylglycerol degradation.SUBUNIT Homodimer.SUBCELLULAR LOCATION Ubiquitous.DISRUPTION PHENOTYPE Mice display a reduction in monoglyceride hydrolase activity and a concomitant increase in monoglyceride levels in adipose tissue, brain, and liver (PubMed:20554061). Ten-fold increase in brain 2-arachidonoylglycerol levels, combined with low levels of brain arachidonic acid (PubMed:20554061, PubMed:20729846).MISCELLANEOUS Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity.SIMILARITY Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 150284
description
  • recommendedName: fullName evidence="12"Monoglyceride lipase shortName: MGL ecNumber evidence="4 6 8 9"3.1.1.23 alternativeName: Monoacylglycerol lipase shortName: MAGL
displayName UniProt:O35678 Mgll
geneName
  • Mgll
identifier O35678
isSequenceChanged false
keyword
  • Alternative splicing
  • Cytoplasm
  • Fatty acid biosynthesis
  • Fatty acid metabolism
  • Hydrolase
  • Lipid biosynthesis
  • Lipid degradation
  • Lipid metabolism
  • Membrane
  • Nitration
  • Phosphoprotein
  • Reference proteome
  • Serine esterase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • Mgll
otherIdentifier
  • 10539894
  • 1426785_s_at
  • 1431331_at
  • 1442560_at
  • 1450391_a_at
  • 1453836_a_at
  • 17460665
  • 23945
  • 4334796
  • 4540557
  • 4543879
  • 4551635
  • 4554504
  • 4584001
  • 4609618
  • 4678503
  • 4792911
  • 4846042
  • 4853850
  • 4989707
  • 4992161
  • 5037878
  • 5122501
  • 5160504
  • 5281535
  • 5292727
  • 5336915
  • 5368899
  • 5525317
  • 5532896
  • 5613145
  • 97511_at
  • AJ001118_s_at
  • A_51_P139920
  • A_52_P568977
  • A_52_P609778
  • A_55_P2063311
  • A_55_P2063312
  • A_55_P2063316
  • A_55_P2114863
  • GE41889
  • GO:0005737
  • GO:0005811
  • GO:0005829
  • GO:0006629
  • GO:0006631
  • GO:0006633
  • GO:0009966
  • GO:0016020
  • GO:0016042
  • GO:0016787
  • GO:0019369
  • GO:0019433
  • GO:0030424
  • GO:0030516
  • GO:0043196
  • GO:0043226
  • GO:0045202
  • GO:0046464
  • GO:0047372
  • GO:0050727
  • GO:0051930
  • GO:0052651
  • GO:0052689
  • GO:0060292
  • GO:0098688
  • GO:0098793
  • GO:0099178
  • GO:0150053
  • GO:2000124
  • ILMN_2592925
  • ILMN_2700408
  • ILMN_2857957
  • mMC014119
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MGLL_MOUSE
  • Q3V2R0
  • Q9D9G8
sequenceLength 303
species [Species:48892] Mus musculus
stId uniprot:O35678
url http://purl.uniprot.org/uniprot/O35678
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