Reactome | UniProt:O15533 TAPBP

chain	signal peptide:1-20 chain:21-448
checksum	9F7BF490BA148B08
comment	FUNCTION Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).SUBUNIT Heterodimer with PDIA3; disulfide-linked. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, PDIA3 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP (PubMed:19119025, PubMed:21263072, PubMed:26611325). Interacts with HLA-G-B2M complex; this interaction is required for loading of high affinity peptides (PubMed:21263072). On its own or as part of MHC class I peptide loading complex, interacts with ligand-free MR1 or MR1-B2M complex, providing for stable MR1 pools ready for metabolite antigen processing (PubMed:32958637).INTERACTION Neutrophils, mostly in fully differentiated cells.DOMAIN The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminal region.POLYMORPHISM The 2 alleles of TAPBP; TAPBP01 (Tapasin01) (shown here) and TAPBP02 (Tapasin02); are in linkage disequilibria with the HLA-DRB1 locus in a Japanese population.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Due to a partial intron retention.SEQUENCE CAUTION Probable cloning artifact.ONLINE INFORMATION TAPBP mutation db
crossReference	[DatabaseIdentifier:11787953] GeneCards:TAPBP [DatabaseIdentifier:12369281] RefSeq:NP_757345.2 [DatabaseIdentifier:12369280] RefSeq:NP_757346.2 [DatabaseIdentifier:12369279] RefSeq:NP_003181.3 [DatabaseIdentifier:12285852] Pharos - Targets:O15533 [DatabaseIdentifier:12265348] PRO:O15533 [DatabaseIdentifier:12154100] PDB:6ENY [DatabaseIdentifier:12154256] PDB:7QPD [DatabaseIdentifier:12181857] PDB:7TUE [DatabaseIdentifier:12181858] PDB:3F8U [DatabaseIdentifier:12181856] PDB:7TUG [DatabaseIdentifier:12181855] PDB:7TUF [DatabaseIdentifier:12179544] PDB:7QNG [DatabaseIdentifier:12136996] Orphanet:TAPBP [DatabaseIdentifier:12125569] OpenTargets:ENSG00000231925 [DatabaseIdentifier:11841022] HPA:ENSG00000231925-TAPBP [DatabaseIdentifier:11803475] GlyGen:O15533 [DatabaseIdentifier:11472748] ENSEMBL:ENSG00000206208 [DatabaseIdentifier:11472746] ENSEMBL:ENSG00000231925 [DatabaseIdentifier:11472747] ENSEMBL:ENSG00000112493 [DatabaseIdentifier:11472745] ENSEMBL:ENSG00000206281 [DatabaseIdentifier:11472749] ENSEMBL:ENSG00000236490 [DatabaseIdentifier:11570549] ENSEMBL:ENSP00000363700 [DatabaseIdentifier:11570541] ENSEMBL:ENSP00000402087 [DatabaseIdentifier:11570543] ENSEMBL:ENSP00000378546 [DatabaseIdentifier:11570547] ENSEMBL:ENSP00000372542 [DatabaseIdentifier:11570539] ENSEMBL:ENSP00000372543 [DatabaseIdentifier:11570545] ENSEMBL:ENSP00000372684 [DatabaseIdentifier:11570550] ENSEMBL:ENSP00000514507 [DatabaseIdentifier:11570546] ENSEMBL:ENSP00000372685 [DatabaseIdentifier:11570542] ENSEMBL:ENSP00000447665 [DatabaseIdentifier:11570548] ENSEMBL:ENSP00000419659 [DatabaseIdentifier:11570538] ENSEMBL:ENSP00000404833 [DatabaseIdentifier:11570544] ENSEMBL:ENSP00000407195 [DatabaseIdentifier:11570540] ENSEMBL:ENSP00000395701 [DatabaseIdentifier:11693237] ENSEMBL:ENST00000417059 [DatabaseIdentifier:11693239] ENSEMBL:ENST00000489157 [DatabaseIdentifier:11693249] ENSEMBL:ENST00000426633 [DatabaseIdentifier:11693238] ENSEMBL:ENST00000551943 [DatabaseIdentifier:11693248] ENSEMBL:ENST00000699659 [DatabaseIdentifier:11693246] ENSEMBL:ENST00000434618 [DatabaseIdentifier:11693241] ENSEMBL:ENST00000383198 [DatabaseIdentifier:11693242] ENSEMBL:ENST00000383066 [DatabaseIdentifier:11693247] ENSEMBL:ENST00000395114 [DatabaseIdentifier:11693245] ENSEMBL:ENST00000456807 [DatabaseIdentifier:11693243] ENSEMBL:ENST00000383197 [DatabaseIdentifier:11693240] ENSEMBL:ENST00000374572 [DatabaseIdentifier:11693244] ENSEMBL:ENST00000383065
databaseName	UniProt
dbId	66323
description	recommendedName: fullName evidence="22"Tapasin shortName: TPN shortName: TPSN alternativeName: NGS-17 alternativeName: TAP-associated protein alternativeName: TAP-binding protein
displayName	UniProt:O15533 TAPBP
geneName	TAPBP NGS17 TAPA
identifier	O15533
isSequenceChanged	false
keyword	3D-structure Alternative splicing Direct protein sequencing Disulfide bond Endoplasmic reticulum Glycoprotein Immunoglobulin domain Membrane Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	TAPBP
otherIdentifier	11735502_a_at 11751572_a_at 11756617_a_at 11756618_x_at 11757321_a_at 1555565_PM_s_at 1555565_s_at 17018215 17030026 17032710 17037511 17040221 208829_PM_at 208829_at 210294_PM_at 210294_at 213081_PM_at 213081_at 2950620 2950621 2950622 2950623 2950624 2950625 2950626 2950628 2950630 2950631 2950632 2950633 2950634 2950635 2950636 2950637 2950638 2950639 2950640 2950641 2950642 2950643 2950644 2950645 2950648 2950649 2950650 2950651 2950652 2950653 2950654 2950655 2950657 34178_at 41168_at 6892 74637_at 8125713 8178977 8180166 A_23_P259580 A_23_P315336 A_23_P360291 A_23_P365719 A_33_P3325914 GE54224 GE87404 GO:0000139 GO:0002376 GO:0002398 GO:0002474 GO:0002502 GO:0005515 GO:0005783 GO:0005789 GO:0006457 GO:0006890 GO:0010468 GO:0012505 GO:0016020 GO:0016192 GO:0019885 GO:0023024 GO:0030670 GO:0033116 GO:0042288 GO:0042605 GO:0042824 GO:0044183 GO:0046978 GO:0046979 GO:0050823 GO:0051082 GO:0060090 GO:0061635 GO:0061779 GO:0062061 GO:0065003 GO:0098553 HMNXSV003028171 HMNXSV003032577 HMNXSV003038859 Hs.206770.0.S2_3p_at Hs2.370937.6.S1_3p_s_at ILMN_1742450 ILMN_1773031 ILMN_1782851 PH_hs_0017822 TC06001584.hg TC6_cox_hap2000208.hg TC6_dbb_hap3000194.hg TC6_mcf_hap5000183.hg TC6_qbl_hap6000196.hg g10803729_3p_at g2587057_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-983083] TAPBP [lumenal side of endoplasmic reticulum membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8863976] TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1236750] TAPBP [phagocytic vesicle membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000231925] ENSEMBL:ENSG00000231925 TAPBP [ReferenceDNASequence:12738486] UCSC:O15533 TAPBP [ReferenceDNASequence:12110864] OMIM:601962 TAPBP [ReferenceDNASequence:12051756] NCBI Gene:6892 TAPBP [ReferenceDNASequence:11967663] Monarch:6892 TAPBP [ReferenceDNASequence:11878839] KEGG:hsa:6892 TAPBP [ReferenceDNASequence:11819602] HGNC:11566 TAPBP [ReferenceDNASequence:11337874] BioGPS Gene:6892 TAPBP [ReferenceDNASequence:11399385] COSMIC - genes:TAPBP TAPBP [ReferenceDNASequence:11413983] CTD Gene:6892 TAPBP [ReferenceDNASequence:11436393] dbSNP Gene:6892 TAPBP
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TPSN_HUMAN A2AB91 A2ABC0 B0V003 B0V0A6 B2ZUA4 E9PGM2 O15210 O15272 Q5STJ8 Q5STK6 Q5STQ5 Q5STQ6 Q66K65 Q96KK7 Q9HAN8 Q9UEE0 Q9UEE4 Q9UIZ6 Q9Y6K2
sequenceLength	448
species	[Species:48887] Homo sapiens
stId	uniprot:O15533
url	http://purl.uniprot.org/uniprot/O15533

UniProt:O15533 TAPBP Show undefined attributes

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