UniProt:O15519-2 CFLAR

chain
  • chain:1-376
  • chain:377-480
checksum 8C6D7E92AE1EB672
comment
  • FUNCTION Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells (PubMed:31046799). Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.SUBUNIT TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and CASP8 (PubMed:9880531). A proteolytic fragment (p43) stays associated with the DISC (PubMed:9880531). Also interacts with FADD, CASP8, CASP3, TRAF1, TRAF2 and Bcl-X(L) (in vitro) (PubMed:9208847, PubMed:9326610). Interacts with RIPK1 (By similarity) (PubMed:9208847, PubMed:9326610, PubMed:9880531). Interacts with GMEB1 (PubMed:31046799).SUBUNIT (Microbial infection) Interacts with HBV protein X.INTERACTION Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.INDUCTION Repressed by IL2/interleukin-2 after TCR stimulation, during progression to the S phase of the cell cycle.DOMAIN The caspase domain lacks the active site residues involved in catalysis.PTM Proteolytically processed by CASP8 generating subunit p43 and p12.PTM Deubiquitinated by USP40, leading to stabilization.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the peptidase C14A family.
crossReference
databaseName UniProt
dbId 145326
description
  • recommendedName: CASP8 and FADD-like apoptosis regulator alternativeName: Caspase homolog shortName: CASH alternativeName: Caspase-eight-related protein shortName: Casper alternativeName: Caspase-like apoptosis regulatory protein shortName: CLARP alternativeName: Cellular FLICE-like inhibitory protein shortName: c-FLIP alternativeName: FADD-like antiapoptotic molecule 1 shortName: FLAME-1 alternativeName: Inhibitor of FLICE shortName: I-FLICE alternativeName: MACH-related inducer of toxicity shortName: MRIT alternativeName: Usurpin component recommendedName: CASP8 and FADD-like apoptosis regulator subunit p43 /component component recommendedName: CASP8 and FADD-like apoptosis regulator subunit p12 /component
displayName UniProt:O15519-2 CFLAR
geneName
  • CFLAR
  • CASH
  • CASP8AP1
  • CLARP
  • MRIT
identifier O15519
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Alternative splicing
  • Apoptosis
  • Host-virus interaction
  • Proteomics identification
  • Reference proteome
  • Repeat
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • CFLAR
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • CFLAR_HUMAN
  • B4DJE0
  • B7Z9F9
  • O14673
  • O14674
  • O14675
  • O15137
  • O15138
  • O15356
  • O15510
  • O43618
  • O43619
  • O43620
  • O60458
  • O60459
  • Q53TS6
  • Q54AF1
  • Q96TE4
  • Q9UEW1
sequenceLength 480
species [Species:48887] Homo sapiens
stId uniprot:O15519-2
url http://purl.uniprot.org/uniprot/O15519-2
variantIdentifier O15519-2
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