Reactome | UniProt:O15511 ARPC5

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UniProt:O15511 ARPC5 Show undefined attributes

chain	initiator methionine:1 chain:2-151
checksum	F050B11774EA6E66
comment	FUNCTION Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.INTERACTION Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ARPC5 family.
crossReference	[DatabaseIdentifier:12369159] RefSeq:NP_005708.1 [DatabaseIdentifier:12369158] RefSeq:NP_001257368.1 [DatabaseIdentifier:12285827] Pharos - Targets:O15511 [DatabaseIdentifier:12265318] PRO:O15511 [DatabaseIdentifier:12168163] PDB:6YW7 [DatabaseIdentifier:12168162] PDB:6UHC [DatabaseIdentifier:12125543] OpenTargets:ENSG00000162704 [DatabaseIdentifier:11840996] HPA:ENSG00000162704-ARPC5 [DatabaseIdentifier:11803454] GlyGen:O15511 [DatabaseIdentifier:11787927] GeneCards:ARPC5 [DatabaseIdentifier:11693177] ENSEMBL:ENST00000294742 [DatabaseIdentifier:11693176] ENSEMBL:ENST00000359856 [DatabaseIdentifier:11570477] ENSEMBL:ENSP00000294742 [DatabaseIdentifier:11570478] ENSEMBL:ENSP00000352918 [DatabaseIdentifier:11472712] ENSEMBL:ENSG00000162704
databaseName	UniProt
dbId	50196
description	recommendedName: Actin-related protein 2/3 complex subunit 5 alternativeName: Arp2/3 complex 16 kDa subunit shortName: p16-ARC
displayName	UniProt:O15511 ARPC5
geneName	ARPC5 ARC16
identifier	O15511
isSequenceChanged	false
keyword	3D-structure Acetylation Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Nucleus Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	ARPC5
otherIdentifier	10092 11715685_s_at 11715686_s_at 11715687_x_at 1555797_PM_a_at 1555797_a_at 1569325_PM_at 1569325_at 16697119 211963_PM_s_at 211963_s_at 237387_PM_at 237387_at 2447452 2447453 2447456 2447457 2447458 2447459 2447460 2447461 2447462 2447463 2447465 2447466 2447467 2447468 2447469 2447470 2447471 2447472 2447477 2447478 2447479 2447480 2447481 2524788 2917726 3835023 38392_at 71309_at 7922793 A_23_P126803 A_33_P3338909 A_33_P3420235 GE54069 GE866876 GO:0003779 GO:0005198 GO:0005200 GO:0005515 GO:0005576 GO:0005634 GO:0005737 GO:0005829 GO:0005856 GO:0005885 GO:0005925 GO:0008092 GO:0015629 GO:0016477 GO:0030027 GO:0030036 GO:0030674 GO:0030833 GO:0030863 GO:0034314 GO:0034774 GO:0035861 GO:0042995 GO:0048870 GO:0051015 GO:0060090 GO:0070062 GO:1904813 HMNXSV003033292 HMNXSV003046497 Hs.213793.0.A1_3p_at Hs.82425.1.S2_3p_a_at Hs2.126222.1.A1_3p_at Hs2.82425.2.S1_3p_s_at ILMN_1768394 PH_hs_0022388 PH_hs_0031635 TC01003617.hg p579
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6801071] ARPC5 [secretory granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6806476] ARPC5 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801065] ARPC5 [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-200806] ARPC5 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12738465] UCSC:O15511 ARPC5 [ReferenceDNASequence:12110840] OMIM:604227 ARPC5 [ReferenceDNASequence:12051715] NCBI Gene:10092 ARPC5 [ReferenceDNASequence:11967622] Monarch:10092 ARPC5 [ReferenceDNASequence:11878800] KEGG:hsa:10092 ARPC5 [ReferenceDNASequence:11819576] HGNC:708 ARPC5 [ReferenceDNASequence:11436379] dbSNP Gene:10092 ARPC5 [ReferenceDNASequence:11413933] CTD Gene:10092 ARPC5 [ReferenceDNASequence:11399371] COSMIC - genes:ARPC5 ARPC5 [ReferenceDNASequence:11337833] BioGPS Gene:10092 ARPC5 [ReferenceDNASequence:ensembl:ENSG00000162704] ENSEMBL:ENSG00000162704 ARPC5
referenceTranscript	[ReferenceRNASequence:12550982] RefSeq:NM_001270439.2 ARPC5 [ReferenceRNASequence:12550983] RefSeq:NM_005717.4 ARPC5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ARPC5_HUMAN A6NEC4 Q6PG42
sequenceLength	151
species	[Species:48887] Homo sapiens
stId	uniprot:O15511
url	http://purl.uniprot.org/uniprot/O15511

Referrals

(interactor)	[UndirectedInteraction:11234393] UniProt:P00533 <-> UniProt:O15511 (IntAct) [UndirectedInteraction:11172869] UniProt:P60953 <-> UniProt:O15511 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6801071] ARPC5 [secretory granule lumen] [EntityWithAccessionedSequence:R-HSA-6806476] ARPC5 [extracellular region] [EntityWithAccessionedSequence:R-HSA-6801065] ARPC5 [ficolin-1-rich granule lumen] [EntityWithAccessionedSequence:R-HSA-200806] ARPC5 [cytosol]