Reactome | UniProt:O15389 SIGLEC5

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UniProt:O15389 SIGLEC5 Show undefined attributes

chain	signal peptide:1-16 chain:17-551
checksum	2FEA2B6B341EFEAF
comment	FUNCTION Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.INTERACTION Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.DOMAIN Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.SIMILARITY Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.ONLINE INFORMATION Siglec-5
crossReference	[DatabaseIdentifier:12373711] RefSeq:NP_003821.1 [DatabaseIdentifier:12287073] Pharos - Targets:O15389 [DatabaseIdentifier:12267416] PRO:O15389 [DatabaseIdentifier:12189172] PDB:2ZG3 [DatabaseIdentifier:12189170] PDB:2ZG1 [DatabaseIdentifier:12189171] PDB:2ZG2 [DatabaseIdentifier:12126817] OpenTargets:ENSG00000105501 [DatabaseIdentifier:11842223] HPA:ENSG00000268500-SIGLEC5 [DatabaseIdentifier:11834358] HMDB Protein:HMDBP14227 [DatabaseIdentifier:11804818] GlyGen:O15389 [DatabaseIdentifier:11789196] GeneCards:SIGLEC5 [DatabaseIdentifier:11696226] ENSEMBL:ENST00000683636 [DatabaseIdentifier:11573527] ENSEMBL:ENSP00000507738 [DatabaseIdentifier:11474661] ENSEMBL:ENSG00000268500
databaseName	UniProt
dbId	64482
description	recommendedName: Sialic acid-binding Ig-like lectin 5 shortName: Siglec-5 alternativeName: CD33 antigen-like 2 alternativeName: Obesity-binding protein 2 shortName: OB-BP2 shortName: OB-binding protein 2 cdAntigenNameCD170/cdAntigenName
displayName	UniProt:O15389 SIGLEC5
geneName	SIGLEC5 CD33L2 OBBP2
identifier	O15389
isSequenceChanged	false
keyword	3D-structure Cell adhesion Disulfide bond Glycoprotein Immunoglobulin domain Lectin Membrane Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SIGLEC5
otherIdentifier	11729739_at 16874911 220000_PM_at 220000_at 3839678 3869155 3869157 3869159 3869160 3869161 3869165 3869166 3869167 3869168 3869169 3869170 3869171 3869172 3869173 3869174 3869175 3869176 3869192 3869193 3869194 8038877 8778 90196_at A_24_P48539 GE58313 GO:0005515 GO:0005886 GO:0007155 GO:0016020 GO:0030246 GO:0030667 GO:0033691 GO:0070821 GO:0101003 HMNXSV003018737 HMNXSV003031195 ILMN_1652381 ILMN_1740298 PH_hs_0006411 TC19001784.hg g4502658_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6801283] SIGLEC5 [ficolin-1-rich granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801320] SIGLEC5 [tertiary granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-197711] SIGLEC5 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801292] SIGLEC5 [secretory granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12739463] UCSC:O15389 SIGLEC5 [ReferenceDNASequence:12111766] OMIM:604200 SIGLEC5 [ReferenceDNASequence:12053818] NCBI Gene:8778 SIGLEC5 [ReferenceDNASequence:11969725] Monarch:8778 SIGLEC5 [ReferenceDNASequence:11880753] KEGG:hsa:8778 SIGLEC5 [ReferenceDNASequence:11820853] HGNC:10874 SIGLEC5 [ReferenceDNASequence:11436868] dbSNP Gene:8778 SIGLEC5 [ReferenceDNASequence:11415779] CTD Gene:8778 SIGLEC5 [ReferenceDNASequence:11399829] COSMIC - genes:SIGLEC5 SIGLEC5 [ReferenceDNASequence:11339936] BioGPS Gene:8778 SIGLEC5 [ReferenceDNASequence:ensembl:ENSG00000268500] ENSEMBL:ENSG00000268500 SIGLEC5
referenceTranscript	[ReferenceRNASequence:12555483] RefSeq:NM_003830.4 SIGLEC5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SIGL5_HUMAN
sequenceLength	551
species	[Species:48887] Homo sapiens
stId	uniprot:O15389
url	http://purl.uniprot.org/uniprot/O15389

Referrals

(interactor)	[UndirectedInteraction:11276003] UniProt:O00206 <-> UniProt:O15389 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6801283] SIGLEC5 [ficolin-1-rich granule membrane] [EntityWithAccessionedSequence:R-HSA-6801320] SIGLEC5 [tertiary granule membrane] [EntityWithAccessionedSequence:R-HSA-197711] SIGLEC5 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6801292] SIGLEC5 [secretory granule membrane]