Reactome | UniProt:O15160 POLR1C

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UniProt:O15160 POLR1C Show undefined attributes

chain	initiator methionine:1 chain:2-346
checksum	B7D558BC8F33D92E
comment	FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft.SUBUNIT Component of the RNA polymerase I and RNA polymerase III complexes consisting of at least 13 and 17 subunits, respectively (PubMed:12391170, PubMed:26151409, PubMed:33335104). Pol I complex consists of a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk subunit POLR1F/RPA43 protruding from the core and additional subunits homologous to general transcription factors POLR1E/RPA49 and POLR1G/RPA34. Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex (PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol III complex consists of a ten-subunit catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination (PubMed:12391170, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218).INTERACTION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
crossReference	[DatabaseIdentifier:11470328] ENSEMBL:ENSG00000171453 [DatabaseIdentifier:12363226] RefSeq:NP_001305805.1 [DatabaseIdentifier:12363225] RefSeq:NP_976035.1 [DatabaseIdentifier:12284515] Pharos - Targets:O15160 [DatabaseIdentifier:12263077] PRO:O15160 [DatabaseIdentifier:12142186] PDB:9K3B [DatabaseIdentifier:12142172] PDB:9K2G [DatabaseIdentifier:12142185] PDB:7FJJ [DatabaseIdentifier:12142187] PDB:8IUE [DatabaseIdentifier:12141431] PDB:7VBB [DatabaseIdentifier:12142178] PDB:9K3V [DatabaseIdentifier:12142164] PDB:9K36 [DatabaseIdentifier:12142162] PDB:8ITY [DatabaseIdentifier:12142168] PDB:9FSO [DatabaseIdentifier:12142169] PDB:9FSR [DatabaseIdentifier:12142161] PDB:7D59 [DatabaseIdentifier:12142173] PDB:7AEA [DatabaseIdentifier:12142158] PDB:9LKT [DatabaseIdentifier:12142167] PDB:7AST [DatabaseIdentifier:12142182] PDB:9LXO [DatabaseIdentifier:12142180] PDB:9K3U [DatabaseIdentifier:12141429] PDB:7VBA [DatabaseIdentifier:12142165] PDB:9FSP [DatabaseIdentifier:12142157] PDB:9K39 [DatabaseIdentifier:12142188] PDB:8IUH [DatabaseIdentifier:12142174] PDB:7AE3 [DatabaseIdentifier:12142160] PDB:7D58 [DatabaseIdentifier:12142163] PDB:9K38 [DatabaseIdentifier:12142179] PDB:7AE1 [DatabaseIdentifier:12142175] PDB:7A6H [DatabaseIdentifier:12162789] PDB:8A43 [DatabaseIdentifier:12142184] PDB:7FJI [DatabaseIdentifier:12142166] PDB:9FSQ [DatabaseIdentifier:12142183] PDB:9LXN [DatabaseIdentifier:12142170] PDB:9FSS [DatabaseIdentifier:12141432] PDB:7VBC [DatabaseIdentifier:12142181] PDB:7DU2 [DatabaseIdentifier:12141428] PDB:7OBB [DatabaseIdentifier:12141430] PDB:7OB9 [DatabaseIdentifier:12142159] PDB:7DN3 [DatabaseIdentifier:12141433] PDB:7OBA [DatabaseIdentifier:12135440] Orphanet:POLR1C [DatabaseIdentifier:12124201] OpenTargets:ENSG00000171453 [DatabaseIdentifier:11839675] HPA:ENSG00000171453-POLR1C [DatabaseIdentifier:11829989] HMDB Protein:HMDBP11916 [DatabaseIdentifier:11802083] GlyGen:O15160 [DatabaseIdentifier:11786598] GeneCards:POLR1C [DatabaseIdentifier:11689807] ENSEMBL:ENST00000642195 [DatabaseIdentifier:11689808] ENSEMBL:ENST00000304004 [DatabaseIdentifier:11689809] ENSEMBL:ENST00000607635 [DatabaseIdentifier:11567109] ENSEMBL:ENSP00000496683 [DatabaseIdentifier:11567108] ENSEMBL:ENSP00000496044 [DatabaseIdentifier:11567110] ENSEMBL:ENSP00000307212
databaseName	UniProt
dbId	63499
description	recommendedName: DNA-directed RNA polymerases I and III subunit RPAC1 shortName: DNA-directed RNA polymerase I subunit C shortName: RNA polymerases I and III subunit AC1 alternativeName: AC40 alternativeName: DNA-directed RNA polymerases I and III 40 kDa polypeptide shortName: RPA40 alternativeName: RPA39 alternativeName: RPC40
displayName	UniProt:O15160 POLR1C
geneName	POLR1C POLR1E
identifier	O15160
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant DNA-directed RNA polymerase Leukodystrophy Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	POLR1C
otherIdentifier	11719195_a_at 11740797_x_at 11761303_a_at 17009032 207515_PM_s_at 207515_s_at 209317_PM_at 209317_at 2908053 2908054 2908055 2908056 2908057 2908058 2908059 2908060 2908061 2908062 2908063 2908064 2908065 2908066 2908067 2908068 2908069 2908070 2908071 2908072 2908073 2908074 2908076 2908097 2908099 36460_at 8119842 82329_at 9533 A_14_P119687 A_23_P70409 A_32_P151269 A_33_P3339103 A_33_P3339109 GE54092 GO:0000428 GO:0001650 GO:0003677 GO:0003824 GO:0003899 GO:0005515 GO:0005634 GO:0005654 GO:0005666 GO:0005730 GO:0005736 GO:0005737 GO:0005829 GO:0006351 GO:0006360 GO:0016740 GO:0046983 GO:0140098 HMNXSV003025476 HMNXSV003040440 HMNXSV003042737 ILMN_1746686 ILMN_1767219 PH_hs_0000558 TC06000603.hg g2266928_3p_at g4759045_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1964454] POLR1C [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-63498] POLR1C [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000171453] ENSEMBL:ENSG00000171453 POLR1C [ReferenceDNASequence:12737216] UCSC:O15160 POLR1C [ReferenceDNASequence:12109632] OMIM:610060 POLR1C [ReferenceDNASequence:12049162] NCBI Gene:9533 POLR1C [ReferenceDNASequence:11965069] Monarch:9533 POLR1C [ReferenceDNASequence:11876494] KEGG:hsa:9533 POLR1C [ReferenceDNASequence:11818235] HGNC:20194 POLR1C [ReferenceDNASequence:11436124] dbSNP Gene:9533 POLR1C [ReferenceDNASequence:11411758] CTD Gene:9533 POLR1C [ReferenceDNASequence:11396555] COSMIC - genes:POLR1E POLR1E [ReferenceDNASequence:11399173] COSMIC - genes:POLR1C POLR1C [ReferenceDNASequence:11335280] BioGPS Gene:9533 POLR1C
referenceTranscript	[ReferenceRNASequence:12545059] RefSeq:NM_001318876.2 POLR1C [ReferenceRNASequence:12545060] RefSeq:NM_203290.4 POLR1C
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RPAC1_HUMAN O75395 Q5JTE3
sequenceLength	346
species	[Species:48887] Homo sapiens
stId	uniprot:O15160
url	http://purl.uniprot.org/uniprot/O15160

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