UniProt:O15117 FYB1

chain
  • chain:1-783
checksum 4EE28EF12AA0E457
comment
  • FUNCTION Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).SUBUNIT Part of a complex consisting of SKAP2, FYB1 and PTPNS1 (By similarity). Part of a complex consisting of SKAP2, FYB1 and LILRB3 (By similarity). Part of a complex consisting of SKAP1, FYB1 and CLNK (By similarity). Interacts with CLNK (via its SH2 domain); this interaction allows SKAP1 and FYB1 to recruit FYN to the complex, thus promoting the phosphorylation of CLNK by FYN (By similarity). Interacts with FYN (PubMed:15849195, PubMed:27335501, PubMed:9207119). Interacts with LCP2 (PubMed:27335501, PubMed:9207119). Interacts with SKAP1 (PubMed:10856234, PubMed:15849195, PubMed:16461356, PubMed:27335501, PubMed:9671755, PubMed:9748251, PubMed:9755858). Interacts with SKAP2 (PubMed:10942756, PubMed:9671755, PubMed:9755858). Interacts with FASLG (PubMed:19807924). Interacts with EVL (PubMed:10747096). Interacts with TMEM47 (By similarity). Interacts with LCK (PubMed:27335501).INTERACTION Colocalizes with TMEM47 at cell-cell contacts in podocytes.ALTERNATIVE PRODUCTS Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.PTM T-cell receptor ligation leads to increased tyrosine phosphorylation.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference
databaseName UniProt
dbId 55158
description
  • recommendedName: fullName evidence="28"FYN-binding protein 1 alternativeName: Adhesion and degranulation promoting adaptor protein shortName: ADAP alternativeName: FYB-120/130 shortName: p120/p130 alternativeName: FYN-T-binding protein alternativeName: SLAP-130 alternativeName: SLP-76-associated phosphoprotein
displayName UniProt:O15117 FYB1
geneName
  • FYB1
  • FYB
  • SLAP130
identifier O15117
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cell junction
  • Coiled coil
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • SH3 domain
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • FYB1
otherIdentifier
  • 11724004_a_at
  • 11724005_s_at
  • 11730372_a_at
  • 11730373_a_at
  • 11730374_a_at
  • 16995601
  • 205285_PM_s_at
  • 205285_s_at
  • 211794_PM_at
  • 211794_at
  • 211795_PM_s_at
  • 211795_s_at
  • 227266_PM_s_at
  • 227266_s_at
  • 2533
  • 2854328
  • 2854329
  • 2854330
  • 2854331
  • 2854332
  • 2854333
  • 2854335
  • 2854336
  • 2854338
  • 2854340
  • 2854341
  • 2854343
  • 2854345
  • 2854348
  • 2854349
  • 2854350
  • 2854351
  • 2854355
  • 2854367
  • 2854368
  • 2854369
  • 2854370
  • 2854371
  • 2854379
  • 2854385
  • 2854395
  • 2854396
  • 2854406
  • 2854407
  • 2854408
  • 41819_at
  • 55978_at
  • 61712_at
  • 74675_s_at
  • 8111739
  • A_23_P122127
  • A_24_P393740
  • GE568089
  • GE81027
  • GO:0002376
  • GO:0005102
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0005856
  • GO:0005886
  • GO:0006955
  • GO:0007229
  • GO:0008289
  • GO:0015629
  • GO:0032991
  • GO:0050852
  • GO:0070161
  • GO:0072659
  • HMNXSV003038047
  • Hs.34192.1.A1_3p_at
  • Hs.58435.0.S1_3p_a_at
  • ILMN_1796537
  • ILMN_2280548
  • PH_hs_0023383
  • TC05001295.hg
  • TC05002968.hg
  • U93049_at
  • g7416992_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FYB1_HUMAN
  • A8K2Y8
  • B4DLN2
  • E9PBV9
  • O00359
  • Q9NZI9
sequenceLength 783
species [Species:48887] Homo sapiens
stId uniprot:O15117
url http://purl.uniprot.org/uniprot/O15117
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