UniProt:O15056 SYNJ2

chain
  • chain:1-1496
checksum 7CC9E368585ACF21
comment
  • FUNCTION Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphateSUBUNIT Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.INTERACTION Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340).ALTERNATIVE PRODUCTS Additional isoforms seem to exist.SIMILARITY Belongs to the synaptojanin family.SIMILARITY In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 65420
description
  • recommendedName: Synaptojanin-2 ecNumber evidence="3"3.1.3.36 alternativeName: Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
displayName UniProt:O15056 SYNJ2
geneName
  • SYNJ2
  • KIAA0348
identifier O15056
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Cytoplasm
  • Cytoskeleton
  • Hydrolase
  • Lipid metabolism
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • RNA-binding
  • Synapse
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • SYNJ2
otherIdentifier
  • 11734961_a_at
  • 11750260_a_at
  • 11750857_a_at
  • 11754394_a_at
  • 1555009_PM_a_at
  • 1555009_a_at
  • 17014114
  • 210612_PM_s_at
  • 210612_s_at
  • 212828_PM_at
  • 212828_at
  • 216180_PM_s_at
  • 216180_s_at
  • 216181_PM_at
  • 216181_at
  • 240257_at
  • 2933393
  • 2933394
  • 2933395
  • 2933396
  • 2933404
  • 2933405
  • 2933406
  • 2933407
  • 2933408
  • 2933413
  • 2933414
  • 2933415
  • 2933416
  • 2933417
  • 2933420
  • 2933421
  • 2933422
  • 2933436
  • 2933441
  • 2933445
  • 2933446
  • 2933447
  • 2933450
  • 2933451
  • 2933453
  • 2933454
  • 2933455
  • 2933459
  • 2933460
  • 2933463
  • 2933464
  • 2933465
  • 2933467
  • 2933468
  • 2933472
  • 2933473
  • 2933476
  • 2933477
  • 2933478
  • 2933479
  • 2933480
  • 2933481
  • 2933483
  • 2933484
  • 2933485
  • 2933486
  • 2933487
  • 2933491
  • 2933492
  • 2933495
  • 2933498
  • 2933499
  • 2933501
  • 2933502
  • 2933503
  • 2933505
  • 2933506
  • 2933507
  • 2933508
  • 2933509
  • 2933510
  • 36532_at
  • 57630_at
  • 70556_at
  • 8123006
  • 8871
  • A_14_P125709
  • A_23_P316974
  • A_23_P344719
  • A_24_P294821
  • A_33_P3354990
  • GE56813
  • GO:0003676
  • GO:0003723
  • GO:0004438
  • GO:0004439
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0005856
  • GO:0005886
  • GO:0006629
  • GO:0006644
  • GO:0006661
  • GO:0016020
  • GO:0016192
  • GO:0016787
  • GO:0016791
  • GO:0034596
  • GO:0036092
  • GO:0042995
  • GO:0043813
  • GO:0045121
  • GO:0045202
  • GO:0046486
  • GO:0046856
  • GO:0048471
  • GO:0048488
  • GO:0052629
  • GO:0052658
  • GO:0052866
  • GO:0061024
  • GO:0098793
  • HMNXSV003001608
  • HMNXSV003012097
  • HMNXSV003023119
  • Hs.207911.0.A1_3p_at
  • Hs.306877.0.S1_3p_at
  • Hs.61289.1.S2_3p_at
  • Hs2.61289.2.A1_3p_s_at
  • ILMN_2215119
  • PH_hs_0035978
  • TC06001128.hg
  • g12034891_3p_a_at
  • p33826
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SYNJ2_HUMAN
  • Q5TA13
  • Q5TA16
  • Q5TA19
  • Q86XK0
  • Q8IZA8
  • Q9H226
sequenceLength 1496
species [Species:48887] Homo sapiens
stId uniprot:O15056
url http://purl.uniprot.org/uniprot/O15056
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