UniProt:O15027 SEC16A

chain
  • chain:1-2357
checksum EAE9570BD5CD434B
comment
  • FUNCTION Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity).SUBUNIT SEC16A and SEC16B are each present in multiple copies in a heteromeric complex (PubMed:17192411, PubMed:22355596). Interacts with SEC23A (PubMed:17192411, PubMed:17428803). Interacts with RNF183 and RNF152 (PubMed:29300766). Interacts with LRRK2 (via ROC domain) (PubMed:25201882). Interacts with SEC13 (PubMed:17428803, PubMed:19638414, PubMed:25201882). Interacts with RAB10 (By similarity). Interacts with MIA3 (PubMed:28442536). Interacts with GORASP2 in response to ER stress (PubMed:28067262).INTERACTION SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation (PubMed:17192411). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). MIA3 and LRRK2 are required for its proper localization to ERES (PubMed:17428803, PubMed:19638414, PubMed:22355596, PubMed:25201882, PubMed:28442536). Recruited to microsomal membrane in SAR1-dependent manner (PubMed:17428803).ALTERNATIVE PRODUCTS Ubiquitous. Expressed at higher levels in the pancreas.SIMILARITY Belongs to the SEC16 family.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 67576
description
  • recommendedName: Protein transport protein Sec16A alternativeName: SEC16 homolog A shortName evidence="15"p250
displayName UniProt:O15027 SEC16A
geneName
  • SEC16A
  • KIAA0310
  • SEC16
  • SEC16L
identifier O15027
isSequenceChanged false
keyword
  • Alternative splicing
  • Cytoplasm
  • Endoplasmic reticulum
  • ER-Golgi transport
  • Golgi apparatus
  • Membrane
  • Microsome
  • Phosphoprotein
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • SEC16A
otherIdentifier
  • 11715699_s_at
  • 11746007_a_at
  • 11752727_a_at
  • 11754099_a_at
  • 11754100_x_at
  • 11762697_at
  • 17099980
  • 215696_PM_s_at
  • 215696_s_at
  • 3230018
  • 3230019
  • 3230020
  • 3230021
  • 3230022
  • 3230023
  • 3230025
  • 3230026
  • 3230027
  • 3230028
  • 3230029
  • 3230036
  • 3230037
  • 3230038
  • 3230039
  • 3230041
  • 3230042
  • 3230044
  • 3230045
  • 3230047
  • 3230049
  • 3230050
  • 3230053
  • 3230054
  • 3230055
  • 3230057
  • 3230059
  • 3230060
  • 3230061
  • 3230062
  • 3230063
  • 3230064
  • 3230065
  • 3230066
  • 3230067
  • 3230068
  • 3230073
  • 3230074
  • 3230076
  • 3230079
  • 3230081
  • 3230083
  • 3230084
  • 3230085
  • 3230086
  • 3230087
  • 3230088
  • 3230089
  • 3230090
  • 3230091
  • 3230092
  • 3230093
  • 3230094
  • 3230095
  • 3230096
  • 3230097
  • 3230098
  • 3230099
  • 3230101
  • 3230102
  • 3230104
  • 3230106
  • 3230108
  • 3230110
  • 3230112
  • 3230114
  • 3230116
  • 3230118
  • 3230120
  • 3230122
  • 3230128
  • 3230129
  • 3230130
  • 3230131
  • 35313_at
  • 8165183
  • 9919
  • A_23_P251303
  • A_33_P3382267
  • GE79996
  • GO:0000139
  • GO:0003400
  • GO:0005515
  • GO:0005737
  • GO:0005783
  • GO:0005789
  • GO:0005794
  • GO:0005829
  • GO:0006886
  • GO:0006888
  • GO:0006893
  • GO:0007029
  • GO:0007030
  • GO:0008104
  • GO:0012507
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0021762
  • GO:0031090
  • GO:0032527
  • GO:0034976
  • GO:0048471
  • GO:0048856
  • GO:0050821
  • GO:0051668
  • GO:0070971
  • GO:0070973
  • GO:0072659
  • HMNXSV003033966
  • HMNXSV003053394
  • Hs.5716.1.A1_3p_a_at
  • ILMN_2126344
  • TC09001732.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SC16A_HUMAN
  • A1YCA4
  • J3KNL6
  • Q4G0D7
  • Q5SXP0
  • Q5SXP1
  • Q8N347
  • Q96HP1
sequenceLength 2357
species [Species:48887] Homo sapiens
stId uniprot:O15027
url http://purl.uniprot.org/uniprot/O15027
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