UniProt:O14979 HNRNPDL

chain
  • chain:1-420
checksum 00F631863859D0CA
comment
  • FUNCTION Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.SUBUNIT Interacts with ZNF148 (By similarity). Interacts with TNPO1.INTERACTION Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner.ALTERNATIVE PRODUCTS Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells.INDUCTION Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in macrophages and retinoic acid (RA) in granulocytes (at protein level). Down-regulated by IL4/interleukin-4.PTM Dimethylation of Arg-408 is probably of the asymmetric type.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 232063
description
  • recommendedName: Heterogeneous nuclear ribonucleoprotein D-like shortName: hnRNP D-like shortName: hnRNP DL alternativeName: AU-rich element RNA-binding factor alternativeName: JKT41-binding protein alternativeName: Protein laAUF1
displayName UniProt:O14979 HNRNPDL
geneName
  • HNRNPDL
  • HNRPDL
  • JKTBP
identifier O14979
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Activator
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • DNA-binding
  • Isopeptide bond
  • Limb-girdle muscular dystrophy
  • Methylation
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Repressor
  • RNA-binding
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • HNRNPDL
otherIdentifier
  • 11720626_s_at
  • 11744688_x_at
  • 11746948_a_at
  • 11746949_x_at
  • 11762863_a_at
  • 1554678_PM_s_at
  • 1554678_s_at
  • 16977364
  • 201993_PM_x_at
  • 201993_x_at
  • 209067_PM_s_at
  • 209067_s_at
  • 209068_PM_at
  • 209068_at
  • 212454_3p_x_at
  • 212454_PM_x_at
  • 212454_x_at
  • 2775563
  • 2775564
  • 2775565
  • 2775566
  • 2775567
  • 2775568
  • 2775569
  • 2775570
  • 2775571
  • 2775572
  • 2775573
  • 2775574
  • 2775575
  • 2775576
  • 2775577
  • 2775578
  • 2775579
  • 2775581
  • 2775582
  • 2775584
  • 2775585
  • 2775586
  • 2775587
  • 2775592
  • 2775593
  • 2775594
  • 2775595
  • 2775596
  • 2775597
  • 2775598
  • 2775599
  • 2775600
  • 2775601
  • 2775602
  • 2775603
  • 3969839
  • 3969840
  • 3969841
  • 40576_f_at
  • 57459_at
  • 8101340
  • 9987
  • A_23_P213153
  • A_24_P260300
  • A_24_P9090
  • GE61322
  • GO:0000785
  • GO:0003676
  • GO:0003677
  • GO:0003690
  • GO:0003697
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005681
  • GO:0005737
  • GO:0005829
  • GO:0006396
  • GO:0008143
  • GO:0010468
  • GO:0034046
  • GO:1990904
  • HMNXSV003043226
  • HMNXSV003056156
  • Hs.170311.2.S1_3p_a_at
  • Hs.170311.3.A1_3p_a_at
  • Hs2.372673.3.S1_3p_s_at
  • ILMN_1653432
  • ILMN_1730572
  • PH_hs_0018031
  • TC04001334.hg
  • TC04002612.hg
  • g2780747_3p_s_at
  • g3218539_3p_at
  • g4885422_3p_a_at
  • p27554
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HNRDL_HUMAN
  • Q6SPF2
  • Q7KZ74
  • Q7KZ75
  • Q96IM0
  • Q96S43
sequenceLength 420
species [Species:48887] Homo sapiens
stId uniprot:O14979
url http://purl.uniprot.org/uniprot/O14979
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