UniProt:O14977 AZIN1

chain
  • chain:1-448
checksum DD26B22A993318E4
comment
  • FUNCTION Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240).SUBUNIT Monomer (PubMed:26305948). Interacts with OAZ1 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1 (Probable).INTERACTION Expressed in liver.PTM Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
crossReference
databaseName UniProt
dbId 60862
description
  • recommendedName: Antizyme inhibitor 1 shortName: AZI shortName: AZI1 alternativeName: Ornithine decarboxylase antizyme inhibitor
displayName UniProt:O14977 AZIN1
geneName
  • AZIN1
  • OAZI
  • OAZIN
identifier O14977
isSequenceChanged false
keyword
  • 3D-structure
  • Nucleus
  • Polyamine biosynthesis
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • AZIN1
otherIdentifier
  • 11725106_s_at
  • 11739093_a_at
  • 17079918
  • 1959_at
  • 201772_PM_at
  • 201772_at
  • 212461_PM_at
  • 212461_at
  • 3147590
  • 3147592
  • 3147593
  • 3147594
  • 3147595
  • 3147596
  • 3147597
  • 3147598
  • 3147599
  • 3147600
  • 3147601
  • 3147602
  • 3147603
  • 3147604
  • 3147605
  • 3147606
  • 3147607
  • 3147609
  • 3147610
  • 3147611
  • 3147613
  • 3147614
  • 3147616
  • 3147619
  • 3147620
  • 3147621
  • 3147623
  • 3147624
  • 3147626
  • 3147632
  • 33367_s_at
  • 33368_at
  • 51582
  • 8152222
  • A_23_P157435
  • A_33_P3319491
  • A_33_P3467933
  • GE615988
  • GE62300
  • GE82040
  • GO:0003824
  • GO:0004586
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0006520
  • GO:0006596
  • GO:0016829
  • GO:0033387
  • GO:0042177
  • GO:0042978
  • GO:0098772
  • GO:1902269
  • HMNXSV003002526
  • HMNXSV003004453
  • Hs.278614.1.A1_3p_at
  • ILMN_1656682
  • ILMN_1704550
  • ILMN_2327994
  • PH_hs_0009777
  • PH_hs_0012498
  • TC08001501.hg
  • X76040_at
  • g7706219_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AZIN1_HUMAN
  • A6NCD5
  • Q6IBQ7
  • Q96D20
sequenceLength 448
species [Species:48887] Homo sapiens
stId uniprot:O14977
url http://purl.uniprot.org/uniprot/O14977
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