UniProt:O14907 TAX1BP3

chain
  • initiator methionine:1
  • chain:2-124
checksum FF0BCDF475F682CD
comment
  • FUNCTION May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.SUBUNIT Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1. Interacts with HTLV-1 TAX protein. Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding. Interacts with ADGRB2 (PubMed:21787750).INTERACTION Recruited to the cell membrane by interaction with membrane proteins.TISSUE SPECIFICITY Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 253161
description
  • recommendedName: Tax1-binding protein 3 alternativeName: Glutaminase-interacting protein 3 alternativeName: Tax interaction protein 1 shortName: TIP-1 alternativeName: Tax-interacting protein 1
displayName UniProt:O14907 TAX1BP3
geneName
  • TAX1BP3
  • TIP1
identifier O14907
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cell membrane
  • Cytoplasm
  • Membrane
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Wnt signaling pathway
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • TAX1BP3
otherIdentifier
  • 11715876_at
  • 16839769
  • 209154_PM_at
  • 209154_at
  • 215464_PM_s_at
  • 215464_s_at
  • 30851
  • 3741530
  • 3741531
  • 3741532
  • 3741535
  • 3741537
  • 3741538
  • 3741545
  • 3741546
  • 39416_at
  • 8011407
  • 89919_s_at
  • A_23_P38468
  • GE79004
  • GE85953
  • GO:0001650
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0005856
  • GO:0005886
  • GO:0007266
  • GO:0008013
  • GO:0008285
  • GO:0015629
  • GO:0016020
  • GO:0016055
  • GO:0030178
  • GO:0032489
  • GO:0070062
  • GO:2000009
  • HMNXSV003040735
  • Hs.12956.1.S1_3p_a_at
  • ILMN_1803392
  • PH_hs_0001245
  • PH_hs_0031003
  • TC17002884.hg
  • U90913_at
  • g12005281_3p_at
  • g12005281_3p_x_at
  • p33681
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TX1B3_HUMAN
  • B2RD53
  • D3DTJ6
  • Q7LCQ4
sequenceLength 124
species [Species:48887] Homo sapiens
stId uniprot:O14907
url http://purl.uniprot.org/uniprot/O14907

Referrals

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