UniProt:O14730 RIOK3

chain
  • chain:1-519
checksum 3C3392BAC4ECB912
comment
  • FUNCTION Serine/threonine-protein kinase involved in a ribosome quality control that takes place when ribosomes have stalled, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit (PubMed:39947182, PubMed:39947183, PubMed:40022732). Acts downstream of RNF10: specifically recognizes and binds RPS2/us5 and RPS3/us3 monoubiquitinated by RNF10, promoting degradation of the 40S ribosomal subunit in a kinase-dependent manner (PubMed:39947182, PubMed:39947183, PubMed:40022732). The RNF10-RIOK3 ribosome quality control takes place in response to ribosome subunit imbalance or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR) (PubMed:39947182, PubMed:39947183, PubMed:40022732). Also involved in regulation of type I interferon (IFN)-dependent immune response, possibly by acting as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappa-B signaling pathway (PubMed:19557502).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Interacts with CASP10 (PubMed:19557502). Interacts with IRF3; RIOK3 probably mediates the interaction of TBK1 with IRF3 (PubMed:24807708). Associated with 40S pre-ribosomal particles (PubMed:22072790, PubMed:22418843).INTERACTION Widely expressed.DOMAIN The ubiquitin interaction motif (UIM) specifically recognizes and binds monoubiquitinated RPS2/us5 and RPS3/us3.PTM Autophosphorylated (in vitro).SIMILARITY Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 245743
description
  • recommendedName: fullName evidence="18"Serine/threonine-protein kinase RIO3 ecNumber evidence="9"2.7.11.1 alternativeName: RIO kinase 3 alternativeName: fullName evidence="17"sudD homolog
displayName UniProt:O14730 RIOK3
geneName
  • RIOK3
  • SUDD
identifier O14730
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Antiviral defense
  • ATP-binding
  • Cytoplasm
  • Immunity
  • Innate immunity
  • Kinase
  • Magnesium
  • Metal-binding
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Ribosome biogenesis
  • Serine/threonine-protein kinase
  • Transferase
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • RIOK3
otherIdentifier
  • 11725950_s_at
  • 11725951_at
  • 11747125_a_at
  • 11749176_a_at
  • 16851443
  • 202129_PM_s_at
  • 202129_s_at
  • 202130_PM_at
  • 202130_at
  • 202131_3p_s_at
  • 202131_PM_s_at
  • 202131_s_at
  • 240583_at
  • 32834_r_at
  • 32835_at
  • 3781674
  • 3781675
  • 3781676
  • 3781677
  • 3781682
  • 3781683
  • 3781684
  • 3781685
  • 3781686
  • 3781687
  • 3781688
  • 3781689
  • 3781690
  • 3781691
  • 3781693
  • 3781695
  • 3781696
  • 3781698
  • 3781701
  • 3781702
  • 3781703
  • 3781704
  • 3781705
  • 3781706
  • 3781707
  • 3781709
  • 3781710
  • 3781711
  • 3781712
  • 3781713
  • 79638_at
  • 8020508
  • 8780
  • A_14_P102167
  • A_23_P55578
  • A_23_P55584
  • A_33_P3317850
  • GE61134
  • GO:0000166
  • GO:0002376
  • GO:0003824
  • GO:0004674
  • GO:0005515
  • GO:0005524
  • GO:0005737
  • GO:0005829
  • GO:0006468
  • GO:0007059
  • GO:0016301
  • GO:0016740
  • GO:0030490
  • GO:0030688
  • GO:0031333
  • GO:0032728
  • GO:0039534
  • GO:0042254
  • GO:0043124
  • GO:0045087
  • GO:0045089
  • GO:0046872
  • GO:0051607
  • GO:0071359
  • GO:0089720
  • GO:0098542
  • GO:0098586
  • GO:0106310
  • GO:0140096
  • GO:1990786
  • HMNXSV003050325
  • Hs.209061.0.S1_3p_a_at
  • Hs.209061.0.S3_3p_at
  • ILMN_1724700
  • ILMN_1733747
  • ILMN_2404135
  • PH_hs_0012146
  • TC18000100.hg
  • g4507298_3p_a_at
  • g4507298_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RIOK3_HUMAN
  • Q8IXN9
sequenceLength 519
species [Species:48887] Homo sapiens
stId uniprot:O14730
url http://purl.uniprot.org/uniprot/O14730
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