UniProt:O14646 CHD1

chain
  • chain:1-1710
checksum D888AAA46FDA31B1
comment
  • FUNCTION ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Component of the SAGA complex (By similarity). Interacts with BCLAF1, NCoR, SRP20 and SAFB (By similarity). Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF complex and the U2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1.INTERACTION Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.ALTERNATIVE PRODUCTS Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia.DOMAIN The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).DOMAIN The CHD1 helical C-terminal domain (CHCT) binds DNA and nucleosomes.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SNF2/RAD54 helicase family.
crossReference
databaseName UniProt
dbId 52026
description
  • recommendedName: fullName evidence="17"ATP-dependent chromatin remodeler CHD1 ecNumber evidence="4"3.6.4.- alternativeName: fullName evidence="17"Chromo domain-containing protein 1 shortName: CHD-1
displayName UniProt:O14646 CHD1
geneName
  • CHD1
identifier O14646
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • ATP-binding
  • Chromatin regulator
  • Cytoplasm
  • Disease variant
  • DNA-binding
  • Hydrolase
  • Intellectual disability
  • Nucleotide-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • CHD1
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CHD1_HUMAN
  • Q17RZ3
sequenceLength 1710
species [Species:48887] Homo sapiens
stId uniprot:O14646
url http://purl.uniprot.org/uniprot/O14646
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