Reactome | UniProt:O14594 NCAN

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UniProt:O14594 NCAN Show undefined attributes

chain	signal peptide:1-22 chain:23-1321
checksum	22E21FFA24CE9FB2
comment	FUNCTION May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.SUBCELLULAR LOCATION Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Brain.PTM O-glycosylated; contains chondroitin sulfate.SIMILARITY Belongs to the aggrecan/versican proteoglycan family.ONLINE INFORMATION Neurocan
crossReference	[DatabaseIdentifier:11495331] ENSEMBL:ENSG00000130287 [DatabaseIdentifier:12419162] RefSeq:NP_004377.2 [DatabaseIdentifier:12287477] Pharos - Targets:O14594 [DatabaseIdentifier:12247826] PRO:O14594 [DatabaseIdentifier:12127241] OpenTargets:ENSG00000130287 [DatabaseIdentifier:11842648] HPA:ENSG00000130287-NCAN [DatabaseIdentifier:11829430] HMDB Protein:HMDBP02407 [DatabaseIdentifier:11805278] GlyGen:O14594 [DatabaseIdentifier:11789621] GeneCards:NCAN [DatabaseIdentifier:11726151] ENSEMBL:ENST00000252575 [DatabaseIdentifier:11603452] ENSEMBL:ENSP00000252575
databaseName	UniProt
dbId	61592
description	recommendedName: Neurocan core protein alternativeName: Chondroitin sulfate proteoglycan 3
displayName	UniProt:O14594 NCAN
geneName	NCAN CSPG3 NEUR
identifier	O14594
isSequenceChanged	false
keyword	Calcium Cell adhesion Disulfide bond EGF-like domain Glycoprotein Hyaluronic acid Immunoglobulin domain Lectin Proteoglycan Proteomics identification Reference proteome Repeat Secreted Signal Sushi
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	NCAN
otherIdentifier	11724892_a_at 11752214_a_at 1463 16859969 205143_PM_at 205143_at 32642_at 3825610 3825611 3825612 3825613 3825614 3825615 3825616 3825620 3825621 3825622 3825623 3825624 3825625 3825626 3825627 3825628 3825631 3825632 3825633 3825634 3825635 3825637 3825638 3825639 3825640 3825641 3825642 3825643 3825644 3825645 3825646 3825647 42903_at 8027152 86518_at A_23_P153797 GE54206 GO:0001501 GO:0005509 GO:0005540 GO:0005576 GO:0005615 GO:0005796 GO:0007155 GO:0007417 GO:0030246 GO:0030312 GO:0031012 GO:0043202 GO:0045202 GO:0048856 GO:0072534 HMNXSV003034591 ILMN_1683211 PH_hs_0010081 TC19000370.hg g4758083_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2065072] CSE-NCAN [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065109] C6S-NCAN [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065078] C4S-NCAN [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065244] D2,4(S)2-NCAN [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065258] D4S-NCAN [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-374591] NCAN [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064084] NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064183] XylS-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064055] Gal-Xyl-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064022] Gal-Gal-Xyl-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064231] GlcA-Gal-Gal-Xyl-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9941351] GlcA-Gal-Gal-XylP-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2063963] chondroitin(1)-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2063965] chondroitin(2)-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064208] chondroitin(3)-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064191] C4S-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065082] D4S-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5607519] dermatan-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065144] D2,4(S)2-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065085] D2,4,4(S)3-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9941162] D4,6S-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065077] D2,4,4(S)3-NCAN [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065250] D2,4(S)2-NCAN [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9941364] D4,6S-NCAN [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065228] D4S-NCAN [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2063985] CSE-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064186] C6S-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9941033] C2S6S-NCAN [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064043] C4S-NCAN [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064175] C6S-NCAN [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9941200] C2S6S-NCAN [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2064044] CSE-NCAN [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065111] D2,4,4(S)3-NCAN [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2065259] NCAN [lysosomal lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000130287] ENSEMBL:ENSG00000130287 NCAN [ReferenceDNASequence:12699989] UCSC:O14594 NCAN [ReferenceDNASequence:12112139] OMIM:600826 NCAN [ReferenceDNASequence:12074885] NCBI Gene:1463 NCAN [ReferenceDNASequence:11990792] Monarch:1463 NCAN [ReferenceDNASequence:11900008] KEGG:hsa:1463 NCAN [ReferenceDNASequence:11821278] HGNC:2465 NCAN [ReferenceDNASequence:11430285] dbSNP Gene:1463 NCAN [ReferenceDNASequence:11416412] CTD Gene:1463 NCAN [ReferenceDNASequence:11394229] COSMIC - genes:NCAN NCAN [ReferenceDNASequence:11361003] BioGPS Gene:1463 NCAN
referenceTranscript	[ReferenceRNASequence:12600822] RefSeq:NM_004386.3 NCAN
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NCAN_HUMAN Q9UPK6
sequenceLength	1321
species	[Species:48887] Homo sapiens
stId	uniprot:O14594
url	http://purl.uniprot.org/uniprot/O14594

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