Reactome | UniProt:O09061 Psmb1

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UniProt:O09061 Psmb1 Show undefined attributes

chain	propeptide:1-27 chain:28-240
checksum	22ADBC6ACB3A8D31
comment	FUNCTION Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).SUBUNIT The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:16857966, PubMed:22341445). Interacts with SERPINB2 (By similarity). Interacts with RFPL4A (PubMed:12525704).SUBCELLULAR LOCATION Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.TISSUE SPECIFICITY Detected in liver (at protein level).SIMILARITY Belongs to the peptidase T1B family.
crossReference	[DatabaseIdentifier:12432108] RefSeq:NP_035315.1 [DatabaseIdentifier:12254279] PRO:O09061 [DatabaseIdentifier:12143465] PDB:5L65 [DatabaseIdentifier:12143486] PDB:5L6A [DatabaseIdentifier:12149050] PDB:3UNB [DatabaseIdentifier:12149045] PDB:3UNE [DatabaseIdentifier:12149046] PDB:8YVP [DatabaseIdentifier:12149047] PDB:3UNF [DatabaseIdentifier:12143463] PDB:5L66 [DatabaseIdentifier:12149049] PDB:8YPK [DatabaseIdentifier:12143488] PDB:5L6C [DatabaseIdentifier:12143445] PDB:5L67 [DatabaseIdentifier:12149048] PDB:3UNH [DatabaseIdentifier:12143443] PDB:5L68 [DatabaseIdentifier:12143485] PDB:5L6B [DatabaseIdentifier:12143449] PDB:5L69 [DatabaseIdentifier:11934291] MGI:104884 [DatabaseIdentifier:11810195] GlyGen:O09061 [DatabaseIdentifier:11735192] ENSEMBL:ENSMUST00000014913 [DatabaseIdentifier:11612493] ENSEMBL:ENSMUSP00000014913 [DatabaseIdentifier:11501758] ENSEMBL:ENSMUSG00000014769
databaseName	UniProt
dbId	99043
description	recommendedName: Proteasome subunit beta type-1 alternativeName: Macropain subunit C5 alternativeName: Multicatalytic endopeptidase complex subunit C5 alternativeName: Proteasome component C5 alternativeName: Proteasome gamma chain alternativeName: Proteasome subunit beta-6 shortName: beta-6
displayName	UniProt:O09061 Psmb1
geneName	Psmb1
identifier	O09061
isSequenceChanged	false
keyword	3D-structure Acetylation Cytoplasm Direct protein sequencing Glycoprotein Nucleus Phosphoprotein Proteasome Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	Psmb1
otherIdentifier	10448048 116776_at 1448166_a_at 160875_at 17341197 19170 4490636 4556314 4600594 4679021 4724547 4872347 4885402 4894427 4899228 4910609 4950532 4978793 5057188 5105036 5137484 5348731 5492861 98113_at A_51_P367162 C81484_rc_s_at GE36521 GO:0000502 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005839 GO:0019774 GO:0051603 ILMN_1239724 Msa.43193.0_f_at mMC009878
physicalEntity	[EntityWithAccessionedSequence:R-MMU-9008786] Psmb1 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-6803287] Psmb1 [secretory granule lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-6806477] Psmb1 [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-MMU-6803340] Psmb1 [ficolin-1-rich granule lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-1236732] Psmb1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-9908143] Psmb1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-9909105] pro-Psmb1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-9908139] Psmb1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-174347] Psmb1 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-68738] Psmb1 [cytosol] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12703739] UCSC:O09061 Psmb1 [ReferenceDNASequence:12080990] NCBI Gene:19170 Psmb1 [ReferenceDNASequence:11996897] Monarch:19170 Psmb1 [ReferenceDNASequence:11905489] KEGG:mmu:19170 Psmb1 [ReferenceDNASequence:11367108] BioGPS Gene:19170 Psmb1
referenceTranscript	[ReferenceRNASequence:12613591] RefSeq:NM_011185.3 Psmb1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PSB1_MOUSE Q62038 Q62039
sequenceLength	240
species	[Species:48892] Mus musculus
stId	uniprot:O09061
url	http://purl.uniprot.org/uniprot/O09061

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