UniProt:O08532 Cacna2d1

chain
  • signal peptide:1-24
  • chain:25-1103
  • chain:25-957
  • chain:958-1103
checksum 103773B4735120D4
comment
  • FUNCTION The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity). Plays an important role in excitation-contraction coupling (By similarity).SUBUNIT Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).INTERACTION Isoform 2A is expressed in skeletal muscle and aorta. Isoform 2B is expressed in brain. Isoform 2C is expressed in heart. Isoform 2D is expressed in heart and smooth muscle. Isoform 2E is expressed in smooth muscle. All five isoforms are expressed in the cardiovascular system.DOMAIN The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.PTM Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.MISCELLANEOUS Binds gabapentin, an antiepileptic drug.SIMILARITY Belongs to the calcium channel subunit alpha-2/delta family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 145412
description
  • recommendedName: Voltage-dependent calcium channel subunit alpha-2/delta-1 alternativeName: Voltage-gated calcium channel subunit alpha-2/delta-1 component recommendedName: Voltage-dependent calcium channel subunit alpha-2-1 /component component recommendedName: Voltage-dependent calcium channel subunit delta-1 /component
displayName UniProt:O08532 Cacna2d1
geneName
  • Cacna2d1
  • Cacna2
identifier O08532
isSequenceChanged false
keyword
  • Alternative splicing
  • Calcium
  • Calcium channel
  • Calcium transport
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Ion channel
  • Ion transport
  • Membrane
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
  • Transport
  • Voltage-gated channel
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Cacna2d1
otherIdentifier
  • 104510_at
  • 10519815
  • 10519855
  • 115657_at
  • 12293
  • 1425861_x_at
  • 1433643_at
  • 1440397_at
  • 1449999_a_at
  • 163248_at
  • 17434890
  • 5038948
  • 5280107
  • A_51_P498720
  • A_52_P160543
  • A_52_P94721
  • A_55_P1988699
  • A_55_P2733132
  • A_55_P2869346
  • A_66_P138052
  • GE35137
  • GO:0005245
  • GO:0005262
  • GO:0005515
  • GO:0005886
  • GO:0005891
  • GO:0006811
  • GO:0006816
  • GO:0016020
  • GO:0016529
  • GO:0030315
  • GO:0034220
  • GO:0034702
  • GO:0046872
  • GO:0048787
  • GO:0051924
  • GO:0055085
  • GO:0060307
  • GO:0060402
  • GO:0061577
  • GO:0070588
  • GO:0086002
  • GO:0086048
  • GO:0086057
  • GO:0086091
  • GO:0098903
  • GO:0098982
  • GO:0098992
  • GO:1902514
  • GO:1904646
  • GO:1990454
  • ILMN_1215110
  • ILMN_1233241
  • ILMN_2568719
  • ILMN_2752030
  • mMC021866
  • u73485_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CA2D1_MOUSE
  • O08533
  • O08534
  • O08535
  • O08536
sequenceLength 1103
species [Species:48892] Mus musculus
stId uniprot:O08532
url http://purl.uniprot.org/uniprot/O08532
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