UniProt:O00451 GFRA2

chain
  • signal peptide:1-21
  • chain:22-444
  • propeptide:445-464
checksum 8BC61529530FF21F
comment
  • FUNCTION Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons (PubMed:10829012, PubMed:29414779, PubMed:31535977, PubMed:9182803). NRTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977). Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (PubMed:9182803).FUNCTION Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.SUBUNIT Interacts with NRTN ligand and RET: forms a 2:2:2 ternary complex composed of NRTN ligand, GFRA2 and RET receptor (PubMed:31535977). Also forms a 4:4:4 tetrameric complex composed of 4 copies of NRTN ligand, GFRA2 and RET receptor, which prevents endocytosis of RET (PubMed:31535977). Interacts with SORL1 (PubMed:23333276).SUBCELLULAR LOCATION found in both brain and placenta.SIMILARITY Belongs to the GDNFR family.
crossReference
databaseName UniProt
dbId 60484
description
  • recommendedName: GDNF family receptor alpha-2 shortName: GDNF receptor alpha-2 shortName: GDNFR-alpha-2 shortName: GFR-alpha-2 alternativeName: GDNF receptor beta shortName: GDNFR-beta alternativeName: Neurturin receptor alpha shortName: NRTNR-alpha shortName: NTNR-alpha alternativeName: RET ligand 2 alternativeName: TGF-beta-related neurotrophic factor receptor 2
displayName UniProt:O00451 GFRA2
geneName
  • GFRA2
  • GDNFRB
  • RETL2
  • TRNR2
identifier O00451
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • GPI-anchor
  • Lipoprotein
  • Membrane
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Signal
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • GFRA2
otherIdentifier
  • 11728937_at
  • 11728938_s_at
  • 11749446_a_at
  • 1692_s_at
  • 17075248
  • 205721_PM_at
  • 205721_at
  • 205722_PM_s_at
  • 205722_s_at
  • 2675
  • 3127160
  • 3127161
  • 3127162
  • 3127163
  • 3127165
  • 3127170
  • 3127171
  • 3127172
  • 3127177
  • 3127183
  • 3127185
  • 3127186
  • 3127187
  • 3127191
  • 3127192
  • 3127193
  • 3127198
  • 38870_at
  • 4049641
  • 4049642
  • 4049646
  • 4049647
  • 4049648
  • 4049649
  • 4049976
  • 8149629
  • AF002700_at
  • A_23_P84084
  • A_24_P96505
  • A_32_P162507
  • A_33_P3317580
  • GE541067
  • GE59604
  • GE80156
  • GO:0005886
  • GO:0007169
  • GO:0007399
  • GO:0009897
  • GO:0016020
  • GO:0016167
  • GO:0019898
  • GO:0035860
  • GO:0038023
  • GO:0043235
  • GO:0048856
  • GO:0098552
  • GO:1904399
  • HMNXSV003042660
  • ILMN_1656300
  • PH_hs_0025835
  • TC08001030.hg
  • g2282027_3p_at
  • g4503982_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GFRA2_HUMAN
  • E9PD47
  • O15316
  • O15328
  • Q58J92
  • Q6GTR9
  • Q7Z5C2
sequenceLength 464
species [Species:48887] Homo sapiens
stId uniprot:O00451
url http://purl.uniprot.org/uniprot/O00451
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