Reactome | UniProt:O00391 QSOX1

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UniProt:O00391 QSOX1 Show undefined attributes

chain	signal peptide:1-29 chain:30-747
checksum	52639D09A50E00C5
comment	FUNCTION Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560).CATALYTIC ACTIVITY 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2COFACTOR Binds 1 FAD per subunit.SUBUNIT Monomer.SUBCELLULAR LOCATION A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor.SUBCELLULAR LOCATION Found in the extracellular medium of quiescent cells but is not found in proliferating cells.ALTERNATIVE PRODUCTS Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.INDUCTION Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter quiescence.PTM N-glycosylated (PubMed:17331072, PubMed:29757379). O-glycosylated on Thr and Ser residues (PubMed:29757379).MISCELLANEOUS 'Quiescin Q6' means that it was the sixth clone to be found at a higher level of expression in quiescent fibroblasts.SIMILARITY Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12422452] RefSeq:NP_002817.2 [DatabaseIdentifier:12422451] RefSeq:NP_001004128.1 [DatabaseIdentifier:12288416] Pharos - Targets:O00391 [DatabaseIdentifier:12249652] PRO:O00391 [DatabaseIdentifier:12203858] PDB:3LLK [DatabaseIdentifier:12203861] PDB:3Q6O [DatabaseIdentifier:12203860] PDB:3LLI [DatabaseIdentifier:12203859] PDB:4IJ3 [DatabaseIdentifier:12128192] OpenTargets:ENSG00000116260 [DatabaseIdentifier:11843578] HPA:ENSG00000116260-QSOX1 [DatabaseIdentifier:11831773] HMDB Protein:HMDBP08287 [DatabaseIdentifier:11806531] GlyGen:O00391 [DatabaseIdentifier:11790574] GeneCards:QSOX1 [DatabaseIdentifier:11728617] ENSEMBL:ENST00000367602 [DatabaseIdentifier:11728616] ENSEMBL:ENST00000367600 [DatabaseIdentifier:11605917] ENSEMBL:ENSP00000356572 [DatabaseIdentifier:11605918] ENSEMBL:ENSP00000356574 [DatabaseIdentifier:11497244] ENSEMBL:ENSG00000116260
databaseName	UniProt
dbId	244553
description	recommendedName: Sulfhydryl oxidase 1 shortName: hQSOX ecNumber evidence="10 13 14 15 17 18 19"1.8.3.2 alternativeName: fullName evidence="23 28"Quiescin Q6
displayName	UniProt:O00391 QSOX1
geneName	QSOX1 QSCN6 UNQ2520/PRO6013
identifier	O00391
isSequenceChanged	false
keyword	3D-structure Alternative splicing Disulfide bond FAD Flavoprotein Glycoprotein Golgi apparatus Membrane Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Secreted Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	QSOX1
otherIdentifier	11715556_a_at 11715557_at 1257_s_at 16674521 201482_PM_at 201482_at 226706_PM_at 226706_at 230523_PM_at 230523_at 2369961 2369962 2369963 2369964 2369969 2369978 2369979 2369986 2369989 2369994 2369995 2370002 2370003 2370005 2370006 2370007 2370008 2370009 2370010 2370011 2370012 2370013 2370014 2370015 2370016 2370017 2370018 2370024 2370025 2370026 2370027 2370029 2370031 56644_at 56685_at 5768 63645_at 7907830 ADDON002362.hg A_14_P138336 A_23_P12463 A_23_P380266 A_23_P380271 A_33_P3220475 A_33_P3225268 A_33_P3225273 GE522835 GE59607 GE840329 GE864856 GO:0000139 GO:0003756 GO:0003824 GO:0005576 GO:0005615 GO:0005788 GO:0005794 GO:0006457 GO:0016020 GO:0016242 GO:0016491 GO:0016853 GO:0016971 GO:0016972 GO:0030198 GO:0031093 GO:0035580 GO:0070062 GO:0071949 GO:0085029 GO:0140096 GO:1904724 HMNXSV003025313 HMNXSV003029963 Hs.28456.0.A1_3p_at Hs.77266.1.A1_3p_at Hs.77266.1.A1_3p_x_at ILMN_1758229 ILMN_2411282 L42379_at PH_hs_0004450 PH_hs_0036301 PH_hs_0036538 TC01001559.hg TC01004863.hg g13325074_3p_at p24815
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6799714] QSOX1 [specific granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800984] QSOX1 [tertiary granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956895] p-QSOX1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956765] QSOX1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800466] QSOX1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8848890] QSOX1 [platelet alpha granule lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12701132] UCSC:O00391 QSOX1 [ReferenceDNASequence:12112984] OMIM:603120 QSOX1 [ReferenceDNASequence:12076637] NCBI Gene:5768 QSOX1 [ReferenceDNASequence:11992544] Monarch:5768 QSOX1 [ReferenceDNASequence:11901570] KEGG:hsa:5768 QSOX1 [ReferenceDNASequence:11822235] HGNC:9756 QSOX1 [ReferenceDNASequence:11430359] dbSNP Gene:5768 QSOX1 [ReferenceDNASequence:11418030] CTD Gene:5768 QSOX1 [ReferenceDNASequence:11394298] COSMIC - genes:QSOX1 QSOX1 [ReferenceDNASequence:11362755] BioGPS Gene:5768 QSOX1 [ReferenceDNASequence:ensembl:ENSG00000116260] ENSEMBL:ENSG00000116260 QSOX1
referenceTranscript	[ReferenceRNASequence:12604028] RefSeq:NM_001004128.3 QSOX1 [ReferenceRNASequence:12604029] RefSeq:NM_002826.4 QSOX1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	QSOX1_HUMAN Q59G29 Q5T2X0 Q8TDL6 Q8WVP4
sequenceLength	747
species	[Species:48887] Homo sapiens
stId	uniprot:O00391
url	http://purl.uniprot.org/uniprot/O00391

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(referenceSequence)

[ModifiedResidue:8956970] phosphorylated residue at unknown position