Reactome | UniProt:O00258 GET1

Schema > ReferenceGeneProduct > Entries

UniProt:O00258 GET1 Show undefined attributes

chain	chain:1-174
checksum	A01F11CC564EAB6E
comment	FUNCTION Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539). Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542).SUBUNIT Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:32910895). Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895). Interacts with CAMLG (via C-terminus) (PubMed:23041287, PubMed:31417168, PubMed:32187542). GET3 shows a higher affinity for CAMLG than for GET1 (PubMed:24392163).INTERACTION Belongs to the WRB/GET1 family.
crossReference	[DatabaseIdentifier:12426616] RefSeq:NP_001139690.1 [DatabaseIdentifier:12426615] RefSeq:NP_001337225.1 [DatabaseIdentifier:12426618] RefSeq:NP_001337223.1 [DatabaseIdentifier:12426617] RefSeq:NP_004618.2 [DatabaseIdentifier:12426614] RefSeq:NP_001337224.1 [DatabaseIdentifier:12289876] Pharos - Targets:O00258 [DatabaseIdentifier:12251595] PRO:O00258 [DatabaseIdentifier:12162085] PDB:8CQZ [DatabaseIdentifier:12157690] PDB:6SO5 [DatabaseIdentifier:12157689] PDB:8CR1 [DatabaseIdentifier:12162084] PDB:8CR2 [DatabaseIdentifier:12129665] OpenTargets:ENSG00000182093 [DatabaseIdentifier:11845026] HPA:ENSG00000182093-GET1 [DatabaseIdentifier:11792031] GeneCards:GET1 [DatabaseIdentifier:11731535] ENSEMBL:ENST00000398753 [DatabaseIdentifier:11731536] ENSEMBL:ENST00000649170 [DatabaseIdentifier:11731533] ENSEMBL:ENST00000380708 [DatabaseIdentifier:11731534] ENSEMBL:ENST00000650376 [DatabaseIdentifier:11608834] ENSEMBL:ENSP00000497103 [DatabaseIdentifier:11608835] ENSEMBL:ENSP00000381737 [DatabaseIdentifier:11608837] ENSEMBL:ENSP00000496813 [DatabaseIdentifier:11608836] ENSEMBL:ENSP00000370084 [DatabaseIdentifier:11499207] ENSEMBL:ENSG00000182093
databaseName	UniProt
dbId	67386
description	recommendedName: fullName evidence="11"Guided entry of tail-anchored proteins factor 1 alternativeName: Congenital heart disease 5 protein alternativeName: Tail-anchored protein insertion receptor WRB alternativeName: Tryptophan-rich basic protein
displayName	UniProt:O00258 GET1
geneName	GET1 CHD5 WRB
identifier	O00258
isSequenceChanged	false
keyword	3D-structure Alternative splicing Coiled coil Endoplasmic reticulum Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	GET1
otherIdentifier	11739305_a_at 11748877_s_at 11748878_x_at 11760995_a_at 11761399_at 11762780_a_at 11762781_at 16922824 202749_at 32777_at 3921392 3921393 3921394 3921395 3921397 3921398 3921399 3921400 3921401 3921402 3921403 3921404 3921405 3921406 3921407 3921408 3921409 3921411 3921412 3921413 3921414 3921415 3921416 3921422 3921424 3921425 3921426 3921428 3921429 3957550 72571_at 72573_g_at 72575_at 7485 80437_at 8068612 A_14_P117203 A_14_P126076 A_23_P80122 GE62709 GO:0005515 GO:0005634 GO:0005783 GO:0005789 GO:0006620 GO:0007605 GO:0016020 GO:0034330 GO:0043495 GO:0043529 GO:0045048 GO:0050808 GO:0050821 GO:0050877 GO:0051649 GO:0060090 GO:0071599 GO:0071816 GO:0090150 HMNXSV003002679 HMNXSV003050506 ILMN_1695092 ILMN_2085922 PH_hs_0011683 PH_hs_0032127 Y12478_at g4759325_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9609521] WRB [endoplasmic reticulum membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12702177] UCSC:O00258 GET1 [ReferenceDNASequence:12114295] OMIM:602915 GET1 [ReferenceDNASequence:12078496] NCBI Gene:7485 GET1 [ReferenceDNASequence:11994403] Monarch:7485 GET1 [ReferenceDNASequence:11903210] KEGG:hsa:7485 GET1 [ReferenceDNASequence:11823709] HGNC:12790 GET1 [ReferenceDNASequence:11430609] dbSNP Gene:7485 GET1 [ReferenceDNASequence:11419982] CTD Gene:7485 GET1 [ReferenceDNASequence:11391844] COSMIC - genes:CHD5 CHD5 [ReferenceDNASequence:11394536] COSMIC - genes:WRB GET1 [ReferenceDNASequence:11364614] BioGPS Gene:7485 GET1 [ReferenceDNASequence:ensembl:ENSG00000182093] ENSEMBL:ENSG00000182093 GET1
referenceTranscript	[ReferenceRNASequence:12608173] RefSeq:NM_001350296.2 GET1 [ReferenceRNASequence:12608176] RefSeq:NM_004627.4 GET1 [ReferenceRNASequence:12608175] RefSeq:NM_001350295.2 GET1 [ReferenceRNASequence:12608177] RefSeq:NM_001146218.3 GET1 [ReferenceRNASequence:12608174] RefSeq:NM_001350294.2 GET1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GET1_HUMAN A8KAP8 A8MQ44 D3DSH9 O60740
sequenceLength	174
species	[Species:48887] Homo sapiens
stId	uniprot:O00258
url	http://purl.uniprot.org/uniprot/O00258

Referrals

(interactor)	[UndirectedInteraction:11297769] UniProt:Q8WTS1 <-> UniProt:O00258 (IntAct) [UndirectedInteraction:11294179] UniProt:Q5QGT7 <-> UniProt:O00258 (IntAct) [UndirectedInteraction:11216281] UniProt:P02652 <-> UniProt:O00258 (IntAct) [UndirectedInteraction:11202457] UniProt:P21964 <-> UniProt:O00258 (IntAct) [UndirectedInteraction:11141715] UniProt:P30825 <-> UniProt:O00258 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9609521] WRB [endoplasmic reticulum membrane]