Reactome | UniProt:O00161 SNAP23

chain	chain:1-211
checksum	AC378E9786C3A239
comment	FUNCTION Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.SUBUNIT Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (PubMed:12556468). Found in a complex with VAMP8 and STX1A (PubMed:12130530). Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).INTERACTION Mainly localized to the plasma membrane.ALTERNATIVE PRODUCTS Ubiquitous. Highest levels where found in placenta.SIMILARITY Belongs to the SNAP-25 family.
crossReference	[DatabaseIdentifier:12425581] RefSeq:XP_054235016.1 [DatabaseIdentifier:12425586] RefSeq:NP_570710.1 [DatabaseIdentifier:12425580] RefSeq:XP_054235017.1 [DatabaseIdentifier:12425582] RefSeq:XP_047289159.1 [DatabaseIdentifier:12425587] RefSeq:XP_016878183.2 [DatabaseIdentifier:11498621] ENSEMBL:ENSG00000092531 [DatabaseIdentifier:11607984] ENSEMBL:ENSP00000380327 [DatabaseIdentifier:11607986] ENSEMBL:ENSP00000207062 [DatabaseIdentifier:11607985] ENSEMBL:ENSP00000249647 [DatabaseIdentifier:11730683] ENSEMBL:ENST00000397138 [DatabaseIdentifier:11730684] ENSEMBL:ENST00000249647 [DatabaseIdentifier:11730685] ENSEMBL:ENST00000349777 [DatabaseIdentifier:11791533] GeneCards:SNAP23 [DatabaseIdentifier:11807549] GlyGen:O00161 [DatabaseIdentifier:11844534] HPA:ENSG00000092531-SNAP23 [DatabaseIdentifier:12129162] OpenTargets:ENSG00000092531 [DatabaseIdentifier:12208659] PDB:1NHL [DatabaseIdentifier:12180687] PDB:3ZUS [DatabaseIdentifier:12251044] PRO:O00161 [DatabaseIdentifier:12289375] Pharos - Targets:O00161 [DatabaseIdentifier:12425585] RefSeq:NP_003816.2 [DatabaseIdentifier:12425584] RefSeq:XP_054235018.1 [DatabaseIdentifier:12425583] RefSeq:XP_047289158.1
databaseName	UniProt
dbId	64694
description	recommendedName: Synaptosomal-associated protein 23 shortName: SNAP-23 alternativeName: Vesicle-membrane fusion protein SNAP-23
displayName	UniProt:O00161 SNAP23
geneName	SNAP23
identifier	O00161
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Cell membrane Coiled coil Direct protein sequencing Lipoprotein Membrane Palmitate Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Synapse Synaptosome Transport
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SNAP23
otherIdentifier	11739173_a_at 11739174_x_at 11741581_s_at 11753568_x_at 11757831_x_at 16800095 209130_PM_at 209130_at 209131_PM_s_at 209131_s_at 214544_PM_s_at 214544_s_at 229773_PM_at 229773_at 32178_r_at 32179_s_at 3591007 3591008 3591009 3591010 3591012 3591013 3591014 3591015 3591016 3591017 3591018 3591019 3591020 3591023 3591024 3591027 3591028 3591029 3591031 3591032 3591033 3591034 3591039 3591040 3591041 46749_i_at 7983111 8773 88736_at A_14_P120636 A_23_P206177 A_33_P3305974 GE564662 GE81326 GO:0002553 GO:0005484 GO:0005515 GO:0005654 GO:0005737 GO:0005739 GO:0005764 GO:0005886 GO:0005912 GO:0005925 GO:0005929 GO:0006887 GO:0006892 GO:0006903 GO:0015031 GO:0016020 GO:0016082 GO:0016192 GO:0019905 GO:0030670 GO:0031201 GO:0031410 GO:0031629 GO:0035579 GO:0042581 GO:0042582 GO:0043005 GO:0043226 GO:0045202 GO:0060090 GO:0061024 GO:0061025 GO:0070062 GO:0070821 GO:0098793 HMNXSV003029186 Hs.122505.0.A1_3p_at ILMN_1687519 ILMN_1748911 PH_hs_0023005 TC15000320.hg U55936_at g13277555_3p_at g1374812_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6806157] SNAP23 [specific granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-376345] SNAP23 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6806141] SNAP23 [tertiary granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8863923] p-S95-SNAP23 [phagocytic vesicle membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8863966] SNAP23 [phagocytic vesicle membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000092531] ENSEMBL:ENSG00000092531 SNAP23 [ReferenceDNASequence:12701849] UCSC:O00161 SNAP23 [ReferenceDNASequence:11364120] BioGPS Gene:8773 SNAP23 [ReferenceDNASequence:11394451] COSMIC - genes:SNAP23 SNAP23 [ReferenceDNASequence:11419312] CTD Gene:8773 SNAP23 [ReferenceDNASequence:11430520] dbSNP Gene:8773 SNAP23 [ReferenceDNASequence:11823204] HGNC:11131 SNAP23 [ReferenceDNASequence:11902790] KEGG:hsa:8773 SNAP23 [ReferenceDNASequence:11993909] Monarch:8773 SNAP23 [ReferenceDNASequence:12078002] NCBI Gene:8773 SNAP23 [ReferenceDNASequence:12113848] OMIM:602534 SNAP23
referenceTranscript	[ReferenceRNASequence:12607147] RefSeq:XM_047433202.1 SNAP23 [ReferenceRNASequence:12607151] RefSeq:XM_054379041.1 SNAP23 [ReferenceRNASequence:12607149] RefSeq:NM_130798.3 SNAP23 [ReferenceRNASequence:12607150] RefSeq:XM_047433203.1 SNAP23 [ReferenceRNASequence:12607153] RefSeq:XM_017022694.2 SNAP23 [ReferenceRNASequence:12607148] RefSeq:XM_054379043.1 SNAP23 [ReferenceRNASequence:12607152] RefSeq:XM_054379042.1 SNAP23 [ReferenceRNASequence:12607154] RefSeq:NM_003825.3 SNAP23
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SNP23_HUMAN O00162 Q13602 Q6IAE3
sequenceLength	211
species	[Species:48887] Homo sapiens
stId	uniprot:O00161
url	http://purl.uniprot.org/uniprot/O00161

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6806157] SNAP23 [specific granule membrane] [EntityWithAccessionedSequence:R-HSA-376345] SNAP23 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6806141] SNAP23 [tertiary granule membrane] [EntityWithAccessionedSequence:R-HSA-8863923] p-S95-SNAP23 [phagocytic vesicle membrane] [EntityWithAccessionedSequence:R-HSA-8863966] SNAP23 [phagocytic vesicle membrane]
(referenceSequence)	[ModifiedResidue:8863932] O-phospho-L-serine at 95
(interactor)	[UndirectedInteraction:11138047] UniProt:Q13277 <-> UniProt:O00161 (IntAct) [UndirectedInteraction:11148973] UniProt:P13569 <-> UniProt:O00161 (IntAct) [UndirectedInteraction:11232127] UniProt:Q16623 <-> UniProt:O00161 (IntAct) [UndirectedInteraction:11269037] UniProt:P54920 <-> UniProt:O00161 (IntAct) [UndirectedInteraction:11300225] UniProt:O00161 <-> UniProt:O75558 (IntAct) [UndirectedInteraction:11300227] UniProt:O00161 <-> UniProt:Q15836 (IntAct) [UndirectedInteraction:11300229] UniProt:O00161 <-> UniProt:Q86Y82 (IntAct) [UndirectedInteraction:11300231] UniProt:O00161 <-> UniProt:O15400 (IntAct) [UndirectedInteraction:11300233] UniProt:O00161 <-> UniProt:Q9H115 (IntAct) [UndirectedInteraction:11300235] UniProt:O00161 <-> UniProt:O76038 (IntAct) [UndirectedInteraction:11300237] UniProt:O00161 <-> UniProt:O95183 (IntAct) [UndirectedInteraction:11300239] UniProt:O00161 <-> UniProt:Q8IUH5 (IntAct) [UndirectedInteraction:11300241] UniProt:O00161 <-> UniProt:P56962 (IntAct)

UniProt:O00161 SNAP23 Show undefined attributes

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