UniProt:F5HFZ4 NEC1

chain
  • chain:1-376
checksum 07A2E48A86AFE140
comment
  • FUNCTION Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.SUBUNIT Forms a heterohexameric complex with NEC2. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.SUBCELLULAR LOCATION Remains attached to the nucleus inner membrane through interaction with NEC2.PTM Phosphorylated at serine residues in the N-terminus. This phosphorylation regulates the localization within the inner nuclear membrane (By similarity). Phosphorylation by viral kinase UL97 at Ser-19 plays an important role for correct viral nuclear egress complex (NEC) localization (By similarity).SIMILARITY Belongs to the herpesviridae NEC1 protein family.
created [InstanceEdit:9037922] Gillespie, Marc E, 2018-02-21
crossReference
databaseName UniProt
dbId 9037896
description
  • recommendedName: fullName evidence="2"Nuclear egress protein 1
displayName UniProt:F5HFZ4 NEC1
geneName
  • NEC1
  • UL53
identifier F5HFZ4
isSequenceChanged false
keyword
  • 3D-structure
  • Host membrane
  • Host nucleus
  • Membrane
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • NEC1
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NEC1_HCMVM
sequenceLength 376
species [Species:2671791] Human cytomegalovirus
stId uniprot:F5HFZ4
url http://purl.uniprot.org/uniprot/F5HFZ4
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