UniProt:F5HB53 gB

chain
  • signal peptide:1-24
  • chain:25-907
checksum C2CE17E8C6E92B00
comment
  • FUNCTION Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.SUBUNIT Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gH/gL heterodimer.SUBCELLULAR LOCATION During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).PTM A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.SIMILARITY Belongs to the herpesviridae glycoprotein B family.
created [InstanceEdit:9037922] Gillespie, Marc E, 2018-02-21
crossReference
databaseName UniProt
dbId 9037871
description
  • recommendedName: fullName evidence="3"Envelope glycoprotein B shortName evidence="3"gB
displayName UniProt:F5HB53 gB
geneName
  • gB
  • UL55
identifier F5HB53
isSequenceChanged false
keyword
  • Disulfide bond
  • Glycoprotein
  • Host cell membrane
  • Host endosome
  • Host Golgi apparatus
  • Host membrane
  • Host-virus interaction
  • Membrane
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
  • Viral attachment to host cell
  • Viral envelope protein
  • Virion
  • Virus entry into host cell
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • gB
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GB_HCMVM
sequenceLength 907
species [Species:2671791] Human cytomegalovirus
stId uniprot:F5HB53
url http://purl.uniprot.org/uniprot/F5HB53
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