UniProt:F5H9F9 UL88

chain
  • chain:1-429
checksum 9D1AAA685AAABD08
comment
  • FUNCTION Plays a role in incorporating a subset of tegument proteins into the virion. It also targets host MYD88, a key component of Toll-like receptor (TLR) signaling, for lysosomal degradation. This leads to suppression of MYD88-dependent immune signaling, weakening the host's antiviral response and promoting viral persistence.SUBUNIT Interacts with UL48. Interacts (via N-terminus) with host MYD88; this interaction promotes lysosomal degradastion of MYD88.SUBCELLULAR LOCATION Accumulates in a juxtanuclear location reminiscent of the viral cytoplasmic assembly compartment.SIMILARITY Belongs to the herpesviridae U59/UL88 family.
created [InstanceEdit:9037922] Gillespie, Marc E, 2018-02-21
crossReference
databaseName UniProt
dbId 9037935
description
  • recommendedName: Protein UL88
displayName UniProt:F5H9F9 UL88
geneName
  • UL88
identifier F5H9F9
isSequenceChanged false
keyword
  • Host cytoplasm
  • Host nucleus
  • Reference proteome
  • Virion
  • Virion tegument
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • UL88
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • UL88_HCMVM
sequenceLength 429
species [Species:2671791] Human cytomegalovirus
stId uniprot:F5H9F9
url http://purl.uniprot.org/uniprot/F5H9F9
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