UniProt:E9Q414 Apob

chain
  • signal peptide:1-27
  • chain:28-4505
  • chain:28-2178
checksum 09EADB2D499E7A82
comment
  • FUNCTION Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.SUBUNIT Interacts with PCSK9 (By similarity). Interacts with MTTP (By similarity). Interacts with AUP1 (By similarity). Interacts with CIDEB (PubMed:19187774, PubMed:23297397).SUBCELLULAR LOCATION Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.RNA EDITING The stop codon (UAA) at position 2179 is created by an APOBEC1-containing mRNA editing complex. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL (By similarity).SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:2239363] May, B, 2012-05-08
crossReference
databaseName UniProt
dbId 2239362
description
  • recommendedName: Apolipoprotein B-100 shortName: Apo B-100 component recommendedName: Apolipoprotein B-48 shortName: Apo B-48 /component
displayName UniProt:E9Q414 Apob
geneName
  • Apob
identifier E9Q414
isSequenceChanged false
keyword
  • Acetylation
  • Cholesterol metabolism
  • Chylomicron
  • Coiled coil
  • Cytoplasm
  • Disulfide bond
  • Glycoprotein
  • Heparin-binding
  • LDL
  • Lipid droplet
  • Lipid metabolism
  • Lipid transport
  • Lipoprotein
  • Palmitate
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • RNA editing
  • Secreted
  • Signal
  • Steroid metabolism
  • Sterol metabolism
  • Transport
  • VLDL
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Apob
otherIdentifier
  • 10394394
  • 1455593_at
  • 1457554_at
  • 17273864
  • 238055
  • 4306053
  • 4384633
  • 4482838
  • 4483189
  • 4487797
  • 4517859
  • 4536182
  • 4559041
  • 4573383
  • 4599026
  • 4608353
  • 4624176
  • 4652178
  • 4673553
  • 4682581
  • 4683372
  • 4709837
  • 4746661
  • 4751261
  • 4778016
  • 4782327
  • 4789210
  • 4848268
  • 4928570
  • 4989594
  • 5104947
  • 5111596
  • 5154650
  • 5176104
  • 5199967
  • 5292540
  • 5394337
  • 5424126
  • 5445027
  • 5459183
  • 5494124
  • 5515030
  • 5569270
  • 5603115
  • 96792_at
  • A_51_P380650
  • A_51_P413088
  • A_51_P436690
  • A_51_P470542
  • A_52_P441070
  • A_55_P1957198
  • A_55_P2743391
  • GE1400721
  • GO:0001701
  • GO:0005215
  • GO:0005319
  • GO:0005543
  • GO:0005576
  • GO:0005615
  • GO:0005737
  • GO:0005783
  • GO:0005811
  • GO:0005829
  • GO:0006629
  • GO:0006642
  • GO:0006869
  • GO:0007018
  • GO:0007165
  • GO:0007283
  • GO:0007399
  • GO:0008201
  • GO:0008202
  • GO:0008203
  • GO:0009566
  • GO:0009615
  • GO:0009791
  • GO:0010628
  • GO:0010744
  • GO:0010884
  • GO:0010886
  • GO:0016042
  • GO:0019433
  • GO:0022414
  • GO:0030163
  • GO:0030301
  • GO:0030317
  • GO:0033344
  • GO:0034359
  • GO:0034361
  • GO:0034362
  • GO:0034363
  • GO:0034374
  • GO:0034383
  • GO:0035473
  • GO:0042157
  • GO:0042158
  • GO:0042159
  • GO:0042627
  • GO:0042632
  • GO:0042953
  • GO:0043025
  • GO:0043226
  • GO:0045540
  • GO:0048018
  • GO:0048844
  • GO:0048856
  • GO:0048870
  • GO:0050750
  • GO:0051649
  • GO:0070971
  • GO:0071402
  • GO:0098772
  • GO:0120020
  • GO:1904646
  • ILMN_2710942
  • Msa.19808.0_s_at
  • Msa.20048.0_s_at
  • mMC010539
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • APOB_MOUSE
  • Q3UH74
  • Q497D8
  • Q61314
  • Q61318
  • Q8CGG8
sequenceLength 4505
species [Species:48892] Mus musculus
stId uniprot:E9Q414
url http://purl.uniprot.org/uniprot/E9Q414

Referrals

(referenceEntity)
(referenceSequence)
Cite Us!