Reactome | UniProt:D3YVF0 Akap5

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UniProt:D3YVF0 Akap5 Show undefined attributes

chain	chain:1-745
checksum	B0A2949CC0F52569
comment	FUNCTION Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (By similarity). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (PubMed:17110924). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses.SUBUNIT Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (By similarity). Interacts with ADCY8, and enhances its phosphorylation at lipid rafts (By similarity). Interacts with ORAI1 (isoform alpha) (via N-terminus) upon store depletion and in response to LTC4. Does not interact with ORAI2 and ORAI3 paralogs. Interacts (via leucine zipper domain) with NFATC2/NFAT1 (By similarity). Interacts with calmodulin; the interaction is calcium-independent (By similarity). Interacts with KCNQ2; the interaction may help KCNQ2 channel complex to retain calcium-bound calmodulin (By similarity). Interacts with KCNK2; the channel is recruited to postsynaptic microdomains by AKAP5 where it can integrate neurotransmitter receptor signals. Part of a complex composed of AKAP5 and ADRB2.INTERACTION Associates with lipid rafts.DOMAIN RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.DOMAIN The N-terminal region, which is highly basic, is required for interaction with calmodulin.PTM Palmitoylated. Palmitoylation at Cys-36 and Cys-123 play a key role in the targeting of AKAP5 to lipid rafts. Palmitoylation by ZDHHC2 is required for AKAP5 function in LTP-stimulated recycling endosome exocytosis.
created	[InstanceEdit:2132304] Weiser, JD
crossReference	[DatabaseIdentifier:12444265] RefSeq:NP_001094941.1 [DatabaseIdentifier:12259883] PRO:D3YVF0 [DatabaseIdentifier:11929884] MGI:2685104 [DatabaseIdentifier:11799552] GlyGen:D3YVF0 [DatabaseIdentifier:11743740] ENSEMBL:ENSMUST00000154078 [DatabaseIdentifier:11621041] ENSEMBL:ENSMUSP00000114495 [DatabaseIdentifier:11507355] ENSEMBL:ENSMUSG00000021057
databaseName	UniProt
dbId	2132394
description	recommendedName: A-kinase anchor protein 5 shortName: AKAP-5 alternativeName: A-kinase anchor protein 150 kDa shortName: AKAP 150 shortName: P150 alternativeName: cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
displayName	UniProt:D3YVF0 Akap5
geneName	Akap5 Akap150
identifier	D3YVF0
isSequenceChanged	false
keyword	Calmodulin-binding Cell membrane Cell projection Endosome Lipoprotein Membrane Palmitate Phosphoprotein Postsynaptic cell membrane Reference proteome Repeat Synapse
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	Akap5
otherIdentifier	10396640 137165_at 1436142_at 1447301_at 17276552 238276 4317449 4317849 4373719 4400347 4462087 4555920 4693953 4989731 5133681 5237627 5259347 5293546 5327624 A_52_P1042732 A_66_P101963 GE132836 GE1449751 GO:0005515 GO:0005516 GO:0005768 GO:0005829 GO:0005856 GO:0005886 GO:0007194 GO:0007416 GO:0008179 GO:0008287 GO:0010467 GO:0014069 GO:0016020 GO:0030425 GO:0031698 GO:0032590 GO:0034237 GO:0034330 GO:0035254 GO:0036394 GO:0042995 GO:0043113 GO:0043197 GO:0043226 GO:0045121 GO:0045163 GO:0045202 GO:0045211 GO:0045762 GO:0050811 GO:0051649 GO:0060076 GO:0060090 GO:0061024 GO:0070073 GO:0070886 GO:0071277 GO:0071466 GO:0098837 GO:0098944 GO:0099630 GO:1905665 ILMN_1234911 ILMN_2440634 mMC007077
physicalEntity	[EntityWithAccessionedSequence:R-MMU-9010693] Akap5 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-381669] Akap5 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-416331] Akap5 [cytosol] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12707236] UCSC:D3YVF0 Akap5 [ReferenceDNASequence:12086421] NCBI Gene:238276 Akap5 [ReferenceDNASequence:12002328] Monarch:238276 Akap5 [ReferenceDNASequence:11910485] KEGG:mmu:238276 Akap5 [ReferenceDNASequence:11372539] BioGPS Gene:238276 Akap5
referenceTranscript	[ReferenceRNASequence:12625818] RefSeq:NM_001101471.1 Akap5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	AKAP5_MOUSE D3Z5C9
sequenceLength	745
species	[Species:48892] Mus musculus
stId	uniprot:D3YVF0
url	http://purl.uniprot.org/uniprot/D3YVF0

Referrals

(interactor)	[UndirectedInteraction:11284415] UniProt:D3YVF0 <-> UniProt:P97438 (IntAct) [UndirectedInteraction:11284413] UniProt:D3YVF0 <-> UniProt:P12367 (IntAct) [UndirectedInteraction:11190039] UniProt:P48453 <-> UniProt:D3YVF0 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-9010693] Akap5 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-381669] Akap5 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-416331] Akap5 [cytosol]

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