Reactome | UniProt:C0HKE7 Hist1h2an

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UniProt:C0HKE7 Hist1h2an Show undefined attributes

chain	initiator methionine:1 chain:2-130
checksum	9CFE6184B2CC89F5
comment	FUNCTION Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SUBUNIT The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SUBCELLULAR LOCATION Deiminated on Arg-4 in granulocytes upon calcium entry.PTM Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.PTM Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.PTM Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.PTM Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex.PTM Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.PTM Hydroxybutyrylation of histones is induced by starvation.PTM Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.SIMILARITY Belongs to the histone H2A family.
created	[InstanceEdit:9015733] Weiser, JD
crossReference	[DatabaseIdentifier:11465257] ENSEMBL:ENSMUSG00000094248 [DatabaseIdentifier:12351332] RefSeq:NP_835491.1 [DatabaseIdentifier:12258123] PRO:C0HKE7 [DatabaseIdentifier:11927846] MGI:2448300 [DatabaseIdentifier:11465258] ENSEMBL:ENSMUSG00000071478 [DatabaseIdentifier:11465256] ENSEMBL:ENSMUSG00000061615 [DatabaseIdentifier:11465263] ENSEMBL:ENSMUSG00000069270 [DatabaseIdentifier:11465261] ENSEMBL:ENSMUSG00000069272 [DatabaseIdentifier:11465262] ENSEMBL:ENSMUSG00000071516 [DatabaseIdentifier:11465259] ENSEMBL:ENSMUSG00000094777 [DatabaseIdentifier:11465260] ENSEMBL:ENSMUSG00000069301 [DatabaseIdentifier:11465264] ENSEMBL:ENSMUSG00000069309 [DatabaseIdentifier:11560512] ENSEMBL:ENSMUSP00000077477 [DatabaseIdentifier:11560506] ENSEMBL:ENSMUSP00000089345 [DatabaseIdentifier:11560508] ENSEMBL:ENSMUSP00000088285 [DatabaseIdentifier:11560505] ENSEMBL:ENSMUSP00000089335 [DatabaseIdentifier:11560513] ENSEMBL:ENSMUSP00000089339 [DatabaseIdentifier:11560507] ENSEMBL:ENSMUSP00000100034 [DatabaseIdentifier:11560509] ENSEMBL:ENSMUSP00000127684 [DatabaseIdentifier:11560511] ENSEMBL:ENSMUSP00000088281 [DatabaseIdentifier:11560510] ENSEMBL:ENSMUSP00000080088 [DatabaseIdentifier:11683205] ENSEMBL:ENSMUST00000091741 [DatabaseIdentifier:11683204] ENSEMBL:ENSMUST00000091751 [DatabaseIdentifier:11683208] ENSEMBL:ENSMUST00000102969 [DatabaseIdentifier:11683206] ENSEMBL:ENSMUST00000090776 [DatabaseIdentifier:11683211] ENSEMBL:ENSMUST00000078369 [DatabaseIdentifier:11683207] ENSEMBL:ENSMUST00000091745 [DatabaseIdentifier:11683212] ENSEMBL:ENSMUST00000081342 [DatabaseIdentifier:11683209] ENSEMBL:ENSMUST00000171127 [DatabaseIdentifier:11683210] ENSEMBL:ENSMUST00000070124
databaseName	UniProt
dbId	9015812
description	recommendedName: fullName evidence="14"Histone H2A type 1-N
displayName	UniProt:C0HKE7 Hist1h2an
geneName	Hist1h2an
identifier	C0HKE7
isSequenceChanged	false
keyword	Acetylation Chromosome Citrullination DNA-binding Hydroxylation Isopeptide bond Methylation Nucleosome core Nucleus Phosphoprotein Reference proteome Ubl conjugation
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	Hist1h2an
otherIdentifier	10403938 10403941 10403955 10404026 10404028 10404045 10404049 10404065 10408072 10408083 10408085 10408094 10408111 10408118 10408202 10408204 10408220 10408239 10408246 10494405 10500324 1438009_at 1460314_s_at 17285677 17285680 17285703 17285838 17291012 17291023 17291057 17291186 17291204 319164 319165 319166 319167 319170 319171 319172 319191 4317557 4321909 4377166 4571512 4598206 4670517 4698780 4705230 4713796 4728274 4755297 4804380 4859434 4925967 5032897 5036590 5078347 5144850 5150983 5164260 5180043 5184161 5246749 5250960 5313600 5351078 5435151 5452333 5495524 5523296 665433 93023_f_at 94805_f_at 96416_f_at A_51_P286460 A_52_P130490 A_52_P420466 A_52_P498210 A_52_P651235 A_55_P2084631 A_55_P2084691 A_55_P2099961 A_55_P2497602 A_55_P2500588 A_66_P115902 GE1391586 GE1442879 GE1483892 GO:0000786 GO:0003677 GO:0005198 GO:0005634 GO:0005694 GO:0006325 GO:0030527 GO:0031507 GO:0043505 GO:0046982 GO:0061644 ILMN_1221342 ILMN_1221597 ILMN_1226839 ILMN_1238276 ILMN_1240660 ILMN_1242304 ILMN_1243240 ILMN_1248830 ILMN_2525581 ILMN_2525595 ILMN_2525605 ILMN_2592253 ILMN_2666418 ILMN_2697777 ILMN_2698519 ILMN_2704873 ILMN_2745212 ILMN_2751102 ILMN_2795040 ILMN_2836654 ILMN_2951691 ILMN_2981801 m37736_f_at mMC005748 mMC012062 mMC019528 mMC020106 mMC022674 mMC023048 mMC025496 mMR027392 mMR029755 mMR029890
physicalEntity	[EntityWithAccessionedSequence:R-MMU-9016567] Hist1h2an [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5229221-6] Hist1h2an [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5229308-6] Hist1h2an [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5244595-6] Hist1h2an [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5244628-6] Hist1h2an [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5244576-6] Hist1h2an [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5244538-6] Hist1h2an [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-6782483-6] Hist1h2an [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-MMU-6783287-6] Hist1h2an [nucleoplasm] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11871608] KEGG:mmu:319172 H2ac7 [ReferenceDNASequence:12734351] UCSC:C0HKE7 Hist1h2an [ReferenceDNASequence:12043464] NCBI Gene:319170 Hist1h2an [ReferenceDNASequence:11959371] Monarch:319170 Hist1h2an [ReferenceDNASequence:11871611] KEGG:mmu:319191 H2ac7 [ReferenceDNASequence:11871607] KEGG:mmu:665433 H2ac7 [ReferenceDNASequence:11871610] KEGG:mmu:319170 H2ac7 [ReferenceDNASequence:11871605] KEGG:mmu:319165 H2ac7 [ReferenceDNASequence:11871606] KEGG:mmu:319164 H2ac7 [ReferenceDNASequence:11871603] KEGG:mmu:319167 H2ac7 [ReferenceDNASequence:11871604] KEGG:mmu:319166 H2ac7 [ReferenceDNASequence:11871609] KEGG:mmu:319171 H2ac7 [ReferenceDNASequence:11329582] BioGPS Gene:319170 Hist1h2an [ReferenceDNASequence:11405236] CTD Gene:319170 Hist1h2an
referenceTranscript	[ReferenceRNASequence:12533190] RefSeq:NM_178184.2 Hist1h2an
schemaClass	ReferenceGeneProduct
secondaryIdentifier	H2A1N_MOUSE P10812 P22752 Q149U0 Q5SZZ2
sequenceLength	130
species	[Species:48892] Mus musculus
stId	uniprot:C0HKE7
url	http://purl.uniprot.org/uniprot/C0HKE7

Referrals

(referenceEntity)

(referenceSequence)

[ModifiedResidue:10052631] omega-N-methyl-L-arginine at 12 (in Homo sapiens)
[ModifiedResidue:10052692] asymmetric dimethyl-L-arginine at 12 (in Homo sapiens)
[ModifiedResidue:10052464] omega-N-methyl-L-arginine at 4 (in Homo sapiens)
[ModifiedResidue:10052525] asymmetric dimethyl-L-arginine at 4 (in Homo sapiens)
[ModifiedResidue:10053255] omega-N-methyl-L-arginine at 30 (in Homo sapiens)
[ModifiedResidue:10053316] asymmetric dimethyl-L-arginine at 30 (in Homo sapiens)
[GroupModifiedResidue:10062416] ubiquitinylated lysine (monoUb [nucleoplasm]) at 120 (in Homo sapiens)
[GroupModifiedResidue:10062960] ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 120 (in Homo sapiens)