UniProt:A8MZ59 LEUTX

chain
  • chain:1-198
checksum F9D921B42E6ED11F
comment
  • FUNCTION Paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). May act as a regulator of embryo genome activation (PubMed:27578796). Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355).FUNCTION Inactive transcriptional activity.INTERACTION During early embryo development, its expression is restricted to the 4-cell to 8-cell stage of the preimplantation embryo.DOMAIN The homeobox contain essential residues (Ile-54, Lys-57, Ala-61) for binding to the 5'-TAATCC-3' motif of the targe gene promoters.DOMAIN The homeobox is incomplete and cannot bind to the 36 bp motif found in the promoters of the target genes.DOMAIN The 9aaTAD motif is a conserved putative nine amino acid transactivation motifs in C-terminus of the LEUTX region.SIMILARITY Belongs to the paired homeobox family.
created [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
crossReference
databaseName UniProt
dbId 385451
description
  • recommendedName: Paired-like homeodomain transcription factor LEUTX alternativeName: Leucine-twenty homeobox alternativeName: fullName evidence="5"Paired-like homeobox transcription factor LEUTX shortName evidence="5"PRD-LIKE homeobox transcription factor LEUTX
displayName UniProt:A8MZ59 LEUTX
geneName
  • LEUTX
identifier A8MZ59
isSequenceChanged false
keyword
  • Alternative initiation
  • DNA-binding
  • Homeobox
  • Nucleus
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • LEUTX
otherIdentifier
  • 11741742_at
  • 16862140
  • 342900
  • 3833267
  • 3833269
  • 3833270
  • 3833271
  • 3833272
  • A_24_P796321
  • GO:0000785
  • GO:0000978
  • GO:0000981
  • GO:0003677
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0006355
  • GO:0006357
  • HMNXSV003045446
  • ILMN_1783808
  • PH_hs_0033798
  • TC19000556.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LEUTX_HUMAN
  • A0A1W2PQ33
sequenceLength 198
species [Species:48887] Homo sapiens
stId uniprot:A8MZ59
url http://purl.uniprot.org/uniprot/A8MZ59

Referrals

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