Reactome | UniProt:A8MXV4 NUDT19

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UniProt:A8MXV4 NUDT19 Show undefined attributes

chain	chain:1-375
checksum	D02AE72BE8615DA3
comment	FUNCTION Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).CATALYTIC ACTIVITY an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY hexanoyl-CoA + H2O = hexanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY malonyl-CoA + H2O = malonyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY succinyl-CoA + H2O = succinyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY choloyl-CoA + H2O = S-choloyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (9Z)-tetradecenoyl-CoA + H2O = S-(9Z-tetradecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (6Z)-octenoyl-CoA + H2O = S-(6Z-octenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)COFACTOR Monomer.SUBCELLULAR LOCATION Belongs to the Nudix hydrolase family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12307666] RefSeq:NP_001099040.1 [DatabaseIdentifier:12280683] Pharos - Targets:A8MXV4 [DatabaseIdentifier:12237769] PRO:A8MXV4 [DatabaseIdentifier:12120346] OpenTargets:ENSG00000213965 [DatabaseIdentifier:11835883] HPA:ENSG00000213965-NUDT19 [DatabaseIdentifier:11830285] HMDB Protein:HMDBP08780 [DatabaseIdentifier:11782769] GeneCards:NUDT19 [DatabaseIdentifier:11652713] ENSEMBL:ENST00000397061 [DatabaseIdentifier:11530014] ENSEMBL:ENSP00000380251 [DatabaseIdentifier:11443902] ENSEMBL:ENSG00000213965
databaseName	UniProt
dbId	240724
description	recommendedName: Acyl-coenzyme A diphosphatase NUDT19 ecNumber: 3.6.1.- ecNumber evidence="1"3.6.1.77 alternativeName: Nucleoside diphosphate-linked moiety X motif 19 shortName: Nudix motif 19
displayName	UniProt:A8MXV4 NUDT19
geneName	NUDT19
identifier	A8MXV4
isSequenceChanged	false
keyword	Hydrolase Magnesium Manganese Metal-binding Peroxisome Proteomics identification Reference proteome
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	NUDT19
otherIdentifier	11730496_x_at 16860545 235384_PM_at 235384_at 3829062 3829063 3829064 3829065 3829066 3829067 3829071 3829072 3829073 3829075 390916 63544_at A_23_P39215 A_23_P39223 A_32_P93391 GE834789 GO:0000287 GO:0005739 GO:0005777 GO:0005782 GO:0005829 GO:0006629 GO:0006790 GO:0009062 GO:0010945 GO:0015938 GO:0016787 GO:0016818 GO:0036114 GO:0044580 GO:0046872 GO:0055086 GO:1901289 GO:1902858 GO:2001294 HMNXSV003023267 HMNXSV003043249 Hs.203961.0.A1_3p_at ILMN_1790282 PH_hs_0032157 TC19000429.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9033098] NUDT19 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6809219] NUDT19 [peroxisomal matrix] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12669360] UCSC:A8MXV4 NUDT19 [ReferenceDNASequence:12023366] NCBI Gene:390916 NUDT19 [ReferenceDNASequence:11939273] Monarch:390916 NUDT19 [ReferenceDNASequence:11853229] KEGG:hsa:390916 NUDT19 [ReferenceDNASequence:11814377] HGNC:32036 NUDT19 [ReferenceDNASequence:11426671] dbSNP Gene:390916 NUDT19 [ReferenceDNASequence:11406256] CTD Gene:390916 NUDT19 [ReferenceDNASequence:11391102] COSMIC - genes:NUDT19 NUDT19 [ReferenceDNASequence:11309484] BioGPS Gene:390916 NUDT19 [ReferenceDNASequence:ensembl:ENSG00000213965] ENSEMBL:ENSG00000213965 NUDT19
referenceTranscript	[ReferenceRNASequence:12489795] RefSeq:NM_001105570.2 NUDT19
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NUD19_HUMAN
sequenceLength	375
species	[Species:48887] Homo sapiens
stId	uniprot:A8MXV4
url	http://purl.uniprot.org/uniprot/A8MXV4

Referrals

(interactor)	[UndirectedInteraction:11306149] UniProt:A8MXV4 <-> UniProt:Q8N5S1 (IntAct) [UndirectedInteraction:11296237] UniProt:P10809 <-> UniProt:A8MXV4 (IntAct) [UndirectedInteraction:11223131] UniProt:Q01523 <-> UniProt:A8MXV4 (IntAct) [UndirectedInteraction:11181361] UniProt:O95861 <-> UniProt:A8MXV4 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9033098] NUDT19 [cytosol] [EntityWithAccessionedSequence:R-HSA-6809219] NUDT19 [peroxisomal matrix]

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