UniProt:A7MB62 ACTR2

chain
  • chain:1-394
checksum 1BFA6B442ED1A797
comment
  • FUNCTION ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:11721045, PubMed:15505213, PubMed:17499050). Interacts with AVIL (By similarity).INTERACTION Belongs to the actin family. ARP2 subfamily.
created [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
crossReference
databaseName UniProt
dbId 354511
description
  • recommendedName: Actin-related protein 2 alternativeName: Actin-like protein 2
displayName UniProt:A7MB62 ACTR2
geneName
  • ACTR2
  • ARP2
identifier A7MB62
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Actin-binding
  • ATP-binding
  • Cell projection
  • Cytoplasm
  • Cytoskeleton
  • Nucleotide-binding
  • Nucleus
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • ACTR2
otherIdentifier
  • 538486
  • Bt.3684.1.S1_at
  • GO:0000910
  • GO:0005198
  • GO:0005200
  • GO:0005634
  • GO:0005737
  • GO:0005885
  • GO:0005938
  • GO:0006355
  • GO:0007018
  • GO:0007163
  • GO:0008092
  • GO:0008356
  • GO:0010592
  • GO:0016344
  • GO:0016482
  • GO:0022414
  • GO:0030036
  • GO:0030478
  • GO:0033206
  • GO:0034314
  • GO:0035861
  • GO:0044782
  • GO:0045944
  • GO:0051015
  • GO:0051321
  • GO:0051653
  • GO:0060271
  • GO:0071346
  • GO:1905168
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ARP2_BOVIN
sequenceLength 394
species [Species:48898] Bos taurus
stId uniprot:A7MB62
url http://purl.uniprot.org/uniprot/A7MB62
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