UniProt:A6NND4 OR2AT4

chain
  • chain:1-320
checksum 62E0FB03CCB8EADB
comment
  • FUNCTION Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264).SUBCELLULAR LOCATION Detected in the keratinocytes of the epidermis (at protein level) (PubMed:24999593). Detected in hair follicles in proximal outer root sheath and hair matrix keratinocytes (at protein level) (PubMed:30228264).INDUCTION Down-regulated during spontaneous, apoptosis-driven hair follicles regression (catagen).SIMILARITY Belongs to the G-protein coupled receptor 1 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 240848
description
  • recommendedName: Olfactory receptor 2AT4 alternativeName: Olfactory receptor OR11-265
displayName UniProt:A6NND4 OR2AT4
geneName
  • OR2AT4
identifier A6NND4
isSequenceChanged false
keyword
  • Cell membrane
  • Disulfide bond
  • G-protein coupled receptor
  • Glycoprotein
  • Membrane
  • Olfaction
  • Receptor
  • Reference proteome
  • Sensory transduction
  • Transducer
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • OR2AT4
otherIdentifier
  • 11738742_at
  • 16742186
  • 2538351
  • 2840633
  • 2840646
  • 2867271
  • 2867281
  • 3100478
  • 3382165
  • 3382166
  • 3382173
  • 3382174
  • 3382176
  • 3382177
  • 3382178
  • 3382180
  • 3404467
  • 3404471
  • 341152
  • 7892853
  • 7894919
  • 7950471
  • ADDON002445.hg
  • A_33_P3365621
  • GO:0004930
  • GO:0004984
  • GO:0005886
  • GO:0007165
  • GO:0007186
  • GO:0007608
  • GO:0016020
  • GO:0050877
  • GO:0050911
  • GO:0070374
  • HMNXSV003005340
  • ILMN_1779412
  • TC11002089.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • O2AT4_HUMAN
  • B9EGZ8
sequenceLength 320
species [Species:48887] Homo sapiens
stId uniprot:A6NND4
url http://purl.uniprot.org/uniprot/A6NND4
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