Reactome | UniProt:A6NED2 RCCD1

chain	chain:1-376
checksum	F72566D12352BBAE
comment	FUNCTION Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245).SUBUNIT Found in a complex with KDM8 (PubMed:24981860). Interacts (via N-terminus) with KDM8 (via N-terminus) (PubMed:24981860, PubMed:28455245).INTERACTION Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3).PTM Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-141 by KDM8.CAUTION Postulated to regulate KDM8 histone demethylase activity on di- and trimethylated 'Lys-36' (H3K36me2/me3) of histone H3 (PubMed:24981860). However the demethylase activity of JMJD5 is controversial, as it was later shown to rather act as an endopeptidase that cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. In several studies, JMJD5 was shown not to display any demethylase activity toward methylated H3K36 nor toward other methyllysines in the N-terminal tails of H3 and H4 in vitro (PubMed:28982940).
created	[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
crossReference	[DatabaseIdentifier:12307639] RefSeq:XP_054235147.1 [DatabaseIdentifier:11443881] ENSEMBL:ENSG00000166965 [DatabaseIdentifier:11529990] ENSEMBL:ENSP00000451963 [DatabaseIdentifier:11529991] ENSEMBL:ENSP00000377801 [DatabaseIdentifier:11652689] ENSEMBL:ENST00000394258 [DatabaseIdentifier:11652690] ENSEMBL:ENST00000556618 [DatabaseIdentifier:11782764] GeneCards:RCCD1 [DatabaseIdentifier:11835878] HPA:ENSG00000166965-RCCD1 [DatabaseIdentifier:12120341] OpenTargets:ENSG00000166965 [DatabaseIdentifier:12147709] PDB:6F4T [DatabaseIdentifier:12147708] PDB:6F4R [DatabaseIdentifier:12147707] PDB:6F4S [DatabaseIdentifier:12237749] PRO:A6NED2 [DatabaseIdentifier:12280678] Pharos - Targets:A6NED2 [DatabaseIdentifier:12307640] RefSeq:XP_047289273.1 [DatabaseIdentifier:12307638] RefSeq:XP_054235146.1 [DatabaseIdentifier:12307637] RefSeq:NP_001017919.1 [DatabaseIdentifier:12307641] RefSeq:NP_291022.2 [DatabaseIdentifier:12307642] RefSeq:XP_047289272.1
databaseName	UniProt
dbId	356380
description	recommendedName: RCC1 domain-containing protein 1
displayName	UniProt:A6NED2 RCCD1
geneName	RCCD1
identifier	A6NED2
isSequenceChanged	false
keyword	3D-structure Chromatin regulator Chromosome Hydroxylation Proteomics identification Reference proteome Repeat
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	RCCD1
otherIdentifier	11729737_a_at 11729738_x_at 16805090 226488_PM_at 226488_at 231290_PM_at 231290_at 3608573 3608574 3608575 3608576 3608577 3608578 3608579 3608580 3608581 3608582 3608583 3608584 3608585 3608586 3608587 3608588 3608589 3608590 3608591 3608592 3608593 3608594 3608595 3608604 3608605 3608607 58007_at 58245_at 7986186 91433 A_14_P136694 A_23_P106433 A_23_P106439 GE61837 GO:0005515 GO:0005694 GO:0005829 GO:0005886 GO:0006325 HMNXSV003046201 Hs.14870.0.A1_3p_at Hs.287295.0.A1_3p_at ILMN_1797738 ILMN_2391324 ILMN_2409318 PH_hs_0038664 TC15000874.hg p33782
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9629873] RCCD1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9629871] 3OHR141-RCCD1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000166965] ENSEMBL:ENSG00000166965 RCCD1 [ReferenceDNASequence:12669350] UCSC:A6NED2 RCCD1 [ReferenceDNASequence:11309459] BioGPS Gene:91433 RCCD1 [ReferenceDNASequence:11391101] COSMIC - genes:RCCD1 RCCD1 [ReferenceDNASequence:11406242] CTD Gene:91433 RCCD1 [ReferenceDNASequence:11426669] dbSNP Gene:91433 RCCD1 [ReferenceDNASequence:11814372] HGNC:30457 RCCD1 [ReferenceDNASequence:11853206] KEGG:hsa:91433 RCCD1 [ReferenceDNASequence:11939248] Monarch:91433 RCCD1 [ReferenceDNASequence:12023341] NCBI Gene:91433 RCCD1 [ReferenceDNASequence:12106159] OMIM:617997 RCCD1
referenceTranscript	[ReferenceRNASequence:12489768] RefSeq:XM_047433316.1 RCCD1 [ReferenceRNASequence:12489770] RefSeq:XM_054379171.1 RCCD1 [ReferenceRNASequence:12489769] RefSeq:XM_047433317.1 RCCD1 [ReferenceRNASequence:12489766] RefSeq:NM_033544.2 RCCD1 [ReferenceRNASequence:12489767] RefSeq:NM_001017919.2 RCCD1 [ReferenceRNASequence:12489771] RefSeq:XM_054379172.1 RCCD1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RCCD1_HUMAN B2RTP9 Q29RX6
sequenceLength	376
species	[Species:48887] Homo sapiens
stId	uniprot:A6NED2
url	http://purl.uniprot.org/uniprot/A6NED2

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9629873] RCCD1 [cytosol] [EntityWithAccessionedSequence:R-HSA-9629871] 3OHR141-RCCD1 [cytosol]
(referenceSequence)	[ModifiedResidue:9629864] (3R)-3-hydroxy-L-arginine at 141
(interactor)	[UndirectedInteraction:11132995] UniProt:O60271 <-> UniProt:A6NED2 (IntAct) [UndirectedInteraction:11179831] UniProt:P62875 <-> UniProt:A6NED2 (IntAct) [UndirectedInteraction:11202649] UniProt:A6NED2 <-> UniProt:Q8N371 (IntAct) [UndirectedInteraction:11202651] UniProt:A6NED2 <-> UniProt:P30838 (IntAct) [UndirectedInteraction:11202653] UniProt:A6NED2 <-> UniProt:Q9UPT6 (IntAct) [UndirectedInteraction:11202655] UniProt:A6NED2 <-> UniProt:Q7L273 (IntAct) [UndirectedInteraction:11202657] UniProt:A6NED2 <-> UniProt:Q96CX2 (IntAct) [UndirectedInteraction:11202659] UniProt:A6NED2 <-> UniProt:Q71U36 (IntAct) [UndirectedInteraction:11202661] UniProt:A6NED2 <-> UniProt:Q14642 (IntAct) [UndirectedInteraction:11202663] UniProt:A6NED2 <-> UniProt:Q15814 (IntAct) [UndirectedInteraction:11202665] UniProt:A6NED2 <-> UniProt:Q9P2Y4 (IntAct) [UndirectedInteraction:11202669] UniProt:A6NED2 <-> UniProt:Q9BQS8 (IntAct) [UndirectedInteraction:11202671] UniProt:A6NED2 <-> UniProt:Q15042 (IntAct) [UndirectedInteraction:11202673] UniProt:A6NED2 <-> UniProt:P11142 (IntAct) [UndirectedInteraction:11202677] UniProt:A6NED2 <-> UniProt:P13994 (IntAct)

UniProt:A6NED2 RCCD1 Show undefined attributes

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