UniProt:A6ND01 IZUMO1R

chain
  • signal peptide:1-19
  • chain:20-228
  • propeptide:229-250
checksum CBF2FD967ABAF6E7
comment
  • FUNCTION Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:30517645). The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.SUBUNIT Monomer (PubMed:27309808). Interacts with IZUMO1; the interaction is direct. IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (PubMed:24739963, PubMed:27309808, PubMed:27309818, PubMed:30517645). Interacts with FCRL3/MAIA; FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, thereby permitting species-specific gamete fusion (PubMed:36070373). Interacts with WDR54 (By similarity).INTERACTION GPI-anchored at the oolemma microvilli.ALTERNATIVE PRODUCTS Expressed in unfertilized oocytes (at protein level).PTM The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.MISCELLANEOUS Gene prediction based on similarity to orthologs.SIMILARITY Belongs to the folate receptor family.
created [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
crossReference
databaseName UniProt
dbId 355246
description
  • recommendedName: fullName evidence="10"Sperm-egg fusion protein Juno alternativeName: Folate receptor 4 alternativeName: fullName evidence="2"Folate receptor delta shortName evidence="2"FR-delta alternativeName: fullName evidence="9"IZUMO1 receptor protein JUNO
displayName UniProt:A6ND01 IZUMO1R
geneName
  • IZUMO1R
  • FOLR4
  • JUNO
identifier A6ND01
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Disulfide bond
  • Fertilization
  • Glycoprotein
  • GPI-anchor
  • Lipoprotein
  • Membrane
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Signal
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • IZUMO1R
otherIdentifier
  • 11741904_at
  • 16730191
  • 3345062
  • 3345064
  • 3345066
  • 3345068
  • 3345070
  • 3345072
  • 3345074
  • 3345076
  • 3345078
  • 3345080
  • 3345082
  • 390243
  • 7943226
  • A_24_P206702
  • GO:0005102
  • GO:0005515
  • GO:0005576
  • GO:0005886
  • GO:0007155
  • GO:0007338
  • GO:0007342
  • GO:0009897
  • GO:0016020
  • GO:0022414
  • GO:0031528
  • GO:0035036
  • GO:0038023
  • GO:0042995
  • GO:0061024
  • GO:0098552
  • HMNXSV003051101
  • ILMN_1665902
  • ILMN_2279217
  • TC11000918.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • JUNO_HUMAN
sequenceLength 250
species [Species:48887] Homo sapiens
stId uniprot:A6ND01
url http://purl.uniprot.org/uniprot/A6ND01
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