UniProt:A2AT37 Upf2

chain
  • chain:1-1269
checksum E95314FDF923F01E
comment
  • FUNCTION Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.SUBUNIT Found in a post-splicing messenger ribonucleoprotein (mRNP) complex (By similarity). Associates with the exon junction complex (EJC) (By similarity). Interacts with SMG1, EST1A, UPF3A, UPF3B, EIF4A1 and EIF1 (By similarity). Interacts with UPF1; interaction is promoted by TDRD6 (PubMed:27149095). Interacts with DDX4 (PubMed:27149095).SUBCELLULAR LOCATION Localized in male germ cells.DEVELOPMENTAL STAGE Weakly expressed in neonatal testes and expression increases during the development of spermatocytes and spermatids, in the late meiotic and postmeiotic stages of spermatogenesis.DISRUPTION PHENOTYPE Knockout adult liver results in hepatosteatosis and disruption of liver homeostasis.
created [InstanceEdit:9014667] Orlic-Milacic, Marija, 2017-08-02
crossReference
databaseName UniProt
dbId 9014670
description
  • recommendedName: fullName evidence="2"Regulator of nonsense transcripts 2 alternativeName: fullName evidence="1"Up-frameshift suppressor 2 homolog shortName: Upf2
displayName UniProt:A2AT37 Upf2
geneName
  • Upf2
  • RENT2
identifier A2AT37
isSequenceChanged false
keyword
  • Coiled coil
  • Cytoplasm
  • Nonsense-mediated mRNA decay
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • RNA-binding
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Upf2
otherIdentifier
  • 10469083
  • 1435030_at
  • 17366562
  • 326622
  • 4353622
  • 4389574
  • 4421870
  • 4439962
  • 4489888
  • 4503676
  • 4539848
  • 4593255
  • 4629735
  • 4645932
  • 4807161
  • 4864151
  • 4868951
  • 4908627
  • 4959126
  • 4997549
  • 5030151
  • 5056483
  • 5168915
  • 5193820
  • 5205101
  • 5236247
  • 5299970
  • 5304338
  • 5325967
  • 5379204
  • 5382732
  • 5473227
  • 5495044
  • 5540110
  • 5565730
  • 5609112
  • AA624270_s_at
  • A_52_P318683
  • A_52_P36218
  • A_52_P664280
  • GE1434343
  • GO:0000184
  • GO:0001889
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0006986
  • GO:0031100
  • GO:0035145
  • GO:0036464
  • GO:0042162
  • GO:0043226
  • GO:0048471
  • GO:0048856
  • ILMN_2435845
  • ILMN_2470211
  • mMC020470
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RENT2_MOUSE
sequenceLength 1269
species [Species:48892] Mus musculus
stId uniprot:A2AT37
url http://purl.uniprot.org/uniprot/A2AT37
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