Reactome | UniProt:A0PJZ3 GXYLT2

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UniProt:A0PJZ3 GXYLT2 Show undefined attributes

chain	chain:1-443
checksum	A53878D061AA27D9
comment	FUNCTION Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.CATALYTIC ACTIVITY 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+)SUBCELLULAR LOCATION Belongs to the glycosyltransferase 8 family.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12357263] RefSeq:NP_001073862.1 [DatabaseIdentifier:12282823] Pharos - Targets:A0PJZ3 [DatabaseIdentifier:12261097] PRO:A0PJZ3 [DatabaseIdentifier:12122502] OpenTargets:ENSG00000172986 [DatabaseIdentifier:11838001] HPA:ENSG00000172986-GXYLT2 [DatabaseIdentifier:11832882] HMDB Protein:HMDBP11772 [DatabaseIdentifier:11800449] GlyGen:A0PJZ3 [DatabaseIdentifier:11784911] GeneCards:GXYLT2 [DatabaseIdentifier:11686706] ENSEMBL:ENST00000389617 [DatabaseIdentifier:11564007] ENSEMBL:ENSP00000374268 [DatabaseIdentifier:11468016] ENSEMBL:ENSG00000172986
databaseName	UniProt
dbId	230570
description	recommendedName: Glucoside xylosyltransferase 2 ecNumber evidence="1"2.4.2.42 alternativeName: Glycosyltransferase 8 domain-containing protein 4
displayName	UniProt:A0PJZ3 GXYLT2
geneName	GXYLT2 GLT8D4
identifier	A0PJZ3
isSequenceChanged	false
keyword	Glycoprotein Glycosyltransferase Membrane Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	GXYLT2
otherIdentifier	11731126_at 16942648 235371_PM_at 235371_at 235733_PM_at 235733_at 2629694 2629695 2629696 2629701 2629702 2629703 2629721 2629723 2629729 2629732 2629733 2629737 2629774 2629775 2629776 2629777 2845304 48999_at 727936 8080964 88984_at A_24_P118196 A_32_P3214 GE829901 GE85841 GO:0005886 GO:0016020 GO:0016266 GO:0016740 GO:0016757 GO:0035252 GO:0140563 HMNXSV003049659 Hs.130526.0.A1_3p_at Hs.97600.0.A1_3p_at ILMN_2085844 PH_hs_0031436 TC03003359.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9926322] GXYLT2 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12683329] UCSC:A0PJZ3 GXYLT2 [ReferenceDNASequence:12108108] OMIM:613322 GXYLT2 [ReferenceDNASequence:12046634] NCBI Gene:727936 GXYLT2 [ReferenceDNASequence:11962541] Monarch:727936 GXYLT2 [ReferenceDNASequence:11874367] KEGG:hsa:727936 GXYLT2 [ReferenceDNASequence:11816536] HGNC:33383 GXYLT2 [ReferenceDNASequence:11428166] dbSNP Gene:727936 GXYLT2 [ReferenceDNASequence:11409107] CTD Gene:727936 GXYLT2 [ReferenceDNASequence:11392391] COSMIC - genes:GXYLT2 GXYLT2 [ReferenceDNASequence:11332752] BioGPS Gene:727936 GXYLT2 [ReferenceDNASequence:ensembl:ENSG00000172986] ENSEMBL:ENSG00000172986 GXYLT2
referenceTranscript	[ReferenceRNASequence:12539113] RefSeq:NM_001080393.2 GXYLT2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GXLT2_HUMAN
sequenceLength	443
species	[Species:48887] Homo sapiens
stId	uniprot:A0PJZ3
url	http://purl.uniprot.org/uniprot/A0PJZ3

Referrals

(interactor)	[UndirectedInteraction:11232413] UniProt:A0PJZ3 <-> UniProt:Q9UBM8 (IntAct) [UndirectedInteraction:11232411] UniProt:A0PJZ3 <-> UniProt:A4D1S0 (IntAct) [UndirectedInteraction:11170575] UniProt:Q9Y4Z2 <-> UniProt:A0PJZ3 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9926322] GXYLT2 [plasma membrane]