Reactome | PP1 dephosphorylates RNA Pol II

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PP1 dephosphorylates RNA Pol II Show undefined attributes

catalystActivity	[CatalystActivity:10728272] protein serine/threonine phosphatase activity of CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728274
displayName	PP1 dephosphorylates RNA Pol II
eventOf	[Pathway:R-XTR-9770562] mRNA Polyadenylation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-XTR-9970191] RBBP6 activates CPSF complex - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9970190] PP1 dephosphorylates RNA Pol II - Homo sapiens
input	[Complex:R-XTR-9970178] CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] 13 × [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PP1 dephosphorylates RNA Pol II
output	[Complex:R-XTR-9970254] CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] 13 × [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9970190
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9770562] mRNA Polyadenylation
(precedingEvent)	[BlackBoxEvent:R-XTR-9970191] RBBP6 activates CPSF complex
(inferredTo)	[Reaction:R-HSA-9970190] PP1 dephosphorylates RNA Pol II

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