Reactome | Tyrosine phosphorylation of STAT3 by IL6 receptor

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Tyrosine phosphorylation of STAT3 by IL6 receptor Show undefined attributes

catalystActivity	[CatalystActivity:10728185] protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728187
displayName	Tyrosine phosphorylation of STAT3 by IL6 receptor
eventOf	[Pathway:R-XTR-9958825] Activation of STAT3 by cadherin engagement - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9958877] p-Y705-STAT3 dissociates from IL6 receptor - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-XTR-9958926] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Tyrosine phosphorylation of STAT3 by IL6 receptor
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-XTR-9958930] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:p-Y705-STAT3 [plasma membrane]
precedingEvent	[Reaction:R-XTR-9958878] Tyrosine phosphorylated IL6ST binds STAT3 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9958871
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9958825] Activation of STAT3 by cadherin engagement
(precedingEvent)	[Reaction:R-XTR-9958877] p-Y705-STAT3 dissociates from IL6 receptor
(inferredTo)	[Reaction:R-HSA-9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor

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