Reactome | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA

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PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10731582
displayName	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
eventOf	[Pathway:R-XTR-9948299] Ribosome-associated quality control - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-9954730] PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide - Xenopus tropicalis [Reaction:R-XTR-9954919] ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released - Xenopus tropicalis [BlackBoxEvent:R-XTR-9955731] ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-9954714] PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9954714
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9948299] Ribosome-associated quality control
(inferredTo)	[Pathway:R-HSA-9954714] PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA

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