Reactome | PP2A dephosphorylates serine-127 of YAP1

Schema > Reaction > Entries

PP2A dephosphorylates serine-127 of YAP1 Show undefined attributes

catalystActivity	[CatalystActivity:10726484] protein serine/threonine phosphatase activity of p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10726486
displayName	PP2A dephosphorylates serine-127 of YAP1
eventOf	[Pathway:R-XTR-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9865226] PP2A dephosphorylates serine-127 of YAP1 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-XTR-2028553] phospho-yap1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PP2A dephosphorylates serine-127 of YAP1
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-XTR-1253345] yap1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9865226
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
(precedingEvent)	[Reaction:R-XTR-9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1
(inferredTo)	[Reaction:R-HSA-9865226] PP2A dephosphorylates serine-127 of YAP1