Reactome | Frataxin transfers Fe2+ to ACO2

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Frataxin transfers Fe2+ to ACO2 Show undefined attributes

catalystActivity	[CatalystActivity:10726097] iron chaperone activity of 2 Iron:FXN [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10726099
displayName	Frataxin transfers Fe2+ to ACO2
eventOf	[Pathway:R-XTR-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9854405] Frataxin transfers Fe2+ to ACO2 - Homo sapiens
input	[Complex:R-XTR-1362402] 2 Iron:FXN [mitochondrial matrix] [Complex:R-XTR-9854373] ACO2:3Fe-4S [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Frataxin transfers Fe2+ to ACO2
output	[Complex:R-XTR-9854344] ACO2:4Fe-4S [mitochondrial matrix] [SimpleEntity:R-ALL-113531] Fe2+ [mitochondrial matrix] [EntityWithAccessionedSequence:R-XTR-1362390] fxn [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-9854368] ROS,RNS oxidize ACO2:4Fe-4S - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9854405
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9854311] Maturation of TCA enzymes and regulation of TCA cycle
(inferredTo)	[Reaction:R-HSA-9854405] Frataxin transfers Fe2+ to ACO2