Reactome | Active ALK binds JAK3

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Active ALK binds JAK3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10722773
displayName	Active ALK binds JAK3
eventOf	[Pathway:R-XTR-201556] Signaling by ALK - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9701488] Active ALK phosphorylates JAK3 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9701485] Active ALK binds JAK3 - Homo sapiens
input	[CandidateSet:R-XTR-9850879] Active ALK dimer [plasma membrane] [EntityWithAccessionedSequence:R-XTR-451893] JAK3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active ALK binds JAK3
output	[Complex:R-XTR-9701478] Active ALK:JAK3 [plasma membrane]
precedingEvent	[Reaction:R-XTR-201521] ALK autophosphorylation - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9701485
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-XTR-9701488] Active ALK phosphorylates JAK3
(inferredTo)	[Reaction:R-HSA-9701485] Active ALK binds JAK3

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